Department of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, PR China.
Department of Orthopedics, Peking University Shougang Hospital, No.9 Jinyuanzhuang Rd, Shijingshan District, 100144 Beijing, PR China.
Adv Drug Deliv Rev. 2021 Jul;174:504-534. doi: 10.1016/j.addr.2021.05.007. Epub 2021 May 13.
Bone regenerative engineering provides a great platform for bone tissue regeneration covering cells, growth factors and other dynamic forces for fabricating scaffolds. Diversified biomaterials and their fabrication methods have emerged for fabricating patient specific bioactive scaffolds with controlled microstructures for bridging complex bone defects. The goal of this review is to summarize the points of scaffold design as well as applications for bone regeneration based on both electrospinning and 3D bioprinting. It first briefly introduces biological characteristics of bone regeneration and summarizes the applications of different types of material and the considerations for bone regeneration including polymers, ceramics, metals and composites. We then discuss electrospinning nanofibrous scaffold applied for the bone regenerative engineering with various properties, components and structures. Meanwhile, diverse design in the 3D bioprinting scaffolds for osteogenesis especially in the role of drug and bioactive factors delivery are assembled. Finally, we discuss challenges and future prospects in the development of electrospinning and 3D bioprinting for osteogenesis and prominent strategies and directions in future.
骨再生工程为骨组织再生提供了一个巨大的平台，涵盖了细胞、生长因子和其他动态力量，用于制造支架。为了制造具有控制的微观结构的患者特异性生物活性支架来桥接复杂的骨缺损，出现了多样化的生物材料及其制造方法。本综述的目的是总结支架设计要点以及基于静电纺丝和 3D 生物打印的骨再生应用。它首先简要介绍了骨再生的生物学特性，并总结了不同类型材料的应用以及包括聚合物、陶瓷、金属和复合材料在内的骨再生的考虑因素。然后，我们讨论了应用于具有各种性能、成分和结构的骨再生工程的静电纺丝纳米纤维支架。同时，组装了 3D 生物打印支架在成骨中的不同设计，特别是在药物和生物活性因子传递中的作用。最后，我们讨论了静电纺丝和 3D 生物打印在成骨中的发展挑战和未来展望，并提出了未来的突出策略和方向。
