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社会经济地位对肝移植选择和受者生存的邻里水平效应。

Neighborhood level effects of socioeconomic status on liver transplant selection and recipient survival.

机构信息

Cincinnati Research in Outcomes and Safety in Surgery, Department of Surgery, University of Cincinnati School of Medicine, Cincinnati, Ohio.

University Health Consortium and Department Health Systems Management, Rush University, Chicago, Illinois.

出版信息

Clin Gastroenterol Hepatol. 2014 Nov;12(11):1934-41. doi: 10.1016/j.cgh.2014.05.020. Epub 2014 Jun 4.

Abstract

BACKGROUND & AIMS: Previous studies have reported that patients of higher socioeconomic status (SES) have increased access to liver transplantation and reduced waitlist mortality than patients of lower SES. However, little is known about the association between SES and outcomes after liver transplantation.

METHODS

By using a link between the University HealthSystem Consortium and the Scientific Registry of Transplant Recipients databases, we identified 12,445 patients who underwent liver transplantation from 2007 through 2011. We used a proportional hazards model to assess the effect of SES on patient survival, controlling for characteristics of recipients, donors, geography, and center.

RESULTS

Compared with liver recipients in the lowest SES quintile, those in the highest quintile were more likely to be male, Caucasian, have private insurance, and undergo transplantation when they had lower Model for End-Stage Liver Disease scores. In proportional hazards model analysis, liver recipients of the lowest SES were at an increased risk for death within a median of 2 years after transplantation (hazard ratio, 1.17; 95% confidence interval, 1.02-1.35).

CONCLUSIONS

Patients of lower SES appear to face barriers to liver transplantation, but perioperative outcomes (length of stay, in-hospital mortality, or 30-day readmission) do not differ significantly from those of patients of higher SES. However, fewer patients of low SES survive for 2 years after transplantation, independent of features of the recipient, donor, surgery center, or location.

摘要

背景与目的

先前的研究报告称,社会经济地位(SES)较高的患者比 SES 较低的患者更容易获得肝移植机会,并降低等待名单上的死亡率。然而,人们对 SES 与肝移植后结果之间的关系知之甚少。

方法

通过将大学健康联盟与移植受者登记处数据库进行链接,我们确定了 2007 年至 2011 年间接受肝移植的 12445 名患者。我们使用比例风险模型评估 SES 对患者生存率的影响,同时控制受者、供者、地理位置和中心的特征。

结果

与 SES 最低五分位的肝移植受者相比,SES 最高五分位的患者更可能是男性、白种人、拥有私人保险,并在终末期肝病模型评分较低时接受移植。在比例风险模型分析中,SES 最低五分位的肝移植受者在移植后中位数 2 年内死亡的风险增加(风险比,1.17;95%置信区间,1.02-1.35)。

结论

SES 较低的患者似乎面临肝移植的障碍,但围手术期结局(住院时间、院内死亡率或 30 天再入院率)与 SES 较高的患者没有显著差异。然而,SES 较低的患者在移植后 2 年内的存活率较低,这独立于受者、供者、手术中心或位置的特征。

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