Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester.
Clinical and Experimental Pharmacology, The Paterson Institute for Cancer Research, Manchester, UK.
Ann Oncol. 2015 Jan;26(1):33-39. doi: 10.1093/annonc/mdu207. Epub 2014 Jun 6.
Circulating tumour cells (CTCs) are cells of solid tumour origin detectable in the peripheral blood. Their occurrence is considered a prerequisite step for establishing distant metastases. Metastatic melanoma was the first malignancy in which CTCs were detected and numerous studies have been published on CTC detection in melanoma at various stages of disease. In spite of this, there is no general consensus as to the clinical utility of CTCs in melanoma, largely due to conflicting results from heterogeneous studies and discrepancies in methods of detection between studies. In this review, we examine the possible clinical significance of CTCs in cutaneous, mucosal and ocular melanoma, focusing on detection methods and prognostic value of CTC detection.
循环肿瘤细胞（CTCs）是指在外周血中可检测到的来源于实体瘤的细胞。其出现被认为是建立远处转移的必要步骤。转移性黑色素瘤是首次被检测到 CTC 的恶性肿瘤，并且已经发表了许多关于黑色素瘤在疾病的不同阶段的 CTC 检测的研究。尽管如此，由于来自异质研究的结果存在冲突以及研究之间的检测方法存在差异，CTC 在黑色素瘤中的临床应用仍然没有共识。在这篇综述中，我们研究了 CTC 在皮肤、粘膜和眼部黑色素瘤中的可能临床意义，重点关注 CTC 检测的检测方法和预后价值。
