He Ping, Haswell Stephen J, Pamme Nicole, Archibald Stephen J
Department of Chemistry, University of Hull, Cottingham Road, Hull HU6 7RX, UK.
Department of Chemistry, University of Hull, Cottingham Road, Hull HU6 7RX, UK; Positron Emission Tomography Research Centre, University of Hull, Cottingham Road, Hull HU6 7RX, UK.
Appl Radiat Isot. 2014 Sep;91:64-70. doi: 10.1016/j.apradiso.2014.04.021. Epub 2014 May 14.
Positron emission tomography (PET) is a powerful scientific and clinical tool for the study and visualization of human physiology that can provide important information about metabolism and diseases such as cancer. At present, [(18)F]fluorodeoxyglucose ([(18)F]FDG) is the most frequently used radiotracer for the routine clinical evaluation of malignant tumors in a range of body tissues. FDG synthesis is continuously being developed to improve and simplify the synthetic procedure including the isolation of [(18)F]fluoride from [(18)O]water. There are many methods reported in literature for the isolation of [(18)F]fluoride, including evaporation, coat-capture-elution, the use of cation-exchange resin and electrode trapping. This review article gives an overview of some of the most common methods for the separation of [(18)F]fluoride ions from [(18)O]water, highlighting the potential strength of the methods and also problems and weaknesses for synthesis of (18)F PET tracers.
正电子发射断层扫描（PET）是一种用于人类生理学研究和可视化的强大科学及临床工具，它能够提供有关新陈代谢和癌症等疾病的重要信息。目前，[（18）F]氟脱氧葡萄糖（[（18）F]FDG）是用于一系列身体组织中恶性肿瘤常规临床评估的最常用放射性示踪剂。FDG合成技术不断发展，以改进和简化合成过程，包括从[（18）O]水中分离[（18）F]氟化物。文献中报道了许多分离[（18）F]氟化物的方法，包括蒸发、涂层捕获洗脱、使用阳离子交换树脂和电极捕获。本文综述了从[（18）O]水中分离[（18）F]氟离子的一些最常见方法，突出了这些方法的潜在优势以及合成（18）F PET示踪剂时存在的问题和不足。
