1] Division of Hypothalamic Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA. [2].
1] Division of Endocrinology, Beth Israel Deaconess Medical Center and Harvard Medical School, Harvard University, Boston, Massachusetts, USA. [2].
Nat Neurosci. 2014 Jul;17(7):911-3. doi: 10.1038/nn.3737. Epub 2014 Jun 8.
Whether melanocortin 4 receptors (MC4Rs) in extra-hypothalamic neurons, including cholinergic autonomic pre-ganglionic neurons, are required to control energy and glucose homeostasis is unclear. We found that MC4Rs in sympathetic, but not parasympathetic, pre-ganglionic neurons were required to regulate energy expenditure and body weight, including thermogenic responses to diet and cold exposure and 'beiging' of white adipose tissue. Deletion of Mc4r genes in both sympathetic and parasympathetic cholinergic neurons impaired glucose homeostasis.
尚不清楚位于下丘脑外神经元（包括胆碱能自主节前神经元）中的黑素皮质素 4 受体（MC4R）是否对控制能量和葡萄糖稳态起作用。我们发现，交感神经而非副交感神经节前神经元中的 MC4R 对于调节能量消耗和体重是必需的，包括对饮食和冷暴露的产热反应以及白色脂肪组织的“褐变”。交感和副交感胆碱能神经元中 Mc4r 基因的缺失会损害葡萄糖稳态。
