垃圾进，垃圾出：质膜蛋白质量控制的新见解。
Garbage on, garbage off: new insights into plasma membrane protein quality control.
机构信息
Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 37232-8240, USA.
出版信息
Curr Opin Cell Biol. 2014 Aug;29:92-8. doi: 10.1016/j.ceb.2014.05.001. Epub 2014 Jun 2.
Abstract
Maintenance of cellular protein quality - by restoring misfolded proteins to their native state and by targeting terminally misfolded or damaged proteins for degradation - is a critical function of all cells. To ensure protein quality, cells have evolved various organelle-specific quality control mechanisms responsible for recognizing and responding to misfolded proteins at different subcellular locations of the cell. Recently, several publications have begun to elucidate mechanisms of quality control that operate at the plasma membrane (PM), recognizing misfolded PM proteins and targeting their endocytic trafficking and lysosomal degradation. Here, I discuss these recent developments in our understanding of PM quality control mechanisms and how they relate to global protein quality control strategies in the cell.
摘要
细胞蛋白质质量的维持 - 通过将错误折叠的蛋白质恢复到其天然状态，以及通过靶向终末错误折叠或受损的蛋白质进行降解 - 是所有细胞的关键功能。为了确保蛋白质质量，细胞已经进化出各种细胞器特异性的质量控制机制，负责在细胞的不同亚细胞位置识别和响应错误折叠的蛋白质。最近，有几篇出版物开始阐明在质膜（PM）上起作用的质量控制机制，这些机制识别错误折叠的 PM 蛋白，并靶向它们的内吞运输和溶酶体降解。在这里，我将讨论我们对 PM 质量控制机制的理解的这些最新进展，以及它们与细胞中全局蛋白质质量控制策略的关系。
相似文献
1
Garbage on, garbage off: new insights into plasma membrane protein quality control.垃圾进，垃圾出：质膜蛋白质量控制的新见解。
Curr Opin Cell Biol. 2014 Aug;29:92-8. doi: 10.1016/j.ceb.2014.05.001. Epub 2014 Jun 2.
2
Protein quality control at the plasma membrane.质膜的蛋白质质量控制。
Curr Opin Cell Biol. 2011 Aug;23(4):483-91. doi: 10.1016/j.ceb.2011.04.012. Epub 2011 May 14.
3
The ART-Rsp5 ubiquitin ligase network comprises a plasma membrane quality control system that protects yeast cells from proteotoxic stress.ART-Rsp5泛素连接酶网络包含一个质膜质量控制系统，该系统可保护酵母细胞免受蛋白毒性应激。
Elife. 2013 Apr 16;2:e00459. doi: 10.7554/eLife.00459.
4
Knowns and unknowns of plasma membrane protein degradation in plants.植物质膜蛋白降解的已知和未知因素。
Plant Sci. 2018 Jul;272:55-61. doi: 10.1016/j.plantsci.2018.04.008. Epub 2018 Apr 12.
5
Thiol-disulfide status regulates quality control of prion protein at the plasma membrane.巯基-二硫键状态调节质膜上朊病毒蛋白的质量控制。
FASEB J. 2019 Oct;33(10):11567-11578. doi: 10.1096/fj.201901052R. Epub 2019 Jul 22.
6
Ubiquitin and membrane protein turnover: from cradle to grave.泛素与膜蛋白周转：从摇篮到坟墓。
Annu Rev Biochem. 2012;81:231-59. doi: 10.1146/annurev-biochem-060210-093619. Epub 2012 Mar 8.
7
Mechanisms for quality control of misfolded transmembrane proteins.错误折叠跨膜蛋白的质量控制机制。
Biochim Biophys Acta. 2012 Apr;1818(4):1108-14. doi: 10.1016/j.bbamem.2011.11.007. Epub 2011 Nov 11.
8
Misfolding diverts CFTR from recycling to degradation: quality control at early endosomes.错误折叠使囊性纤维化跨膜传导调节因子从再循环转向降解：早期内体的质量控制。
J Cell Biol. 2004 Mar 15;164(6):923-33. doi: 10.1083/jcb.200312018. Epub 2004 Mar 8.
9
Quality control: quality control at the plasma membrane: one mechanism does not fit all.质量控制：质膜的质量控制：一种机制并不适用于所有情况。
J Cell Biol. 2014 Apr 14;205(1):11-20. doi: 10.1083/jcb.201310113.
10
Phosphorylation-dependent trafficking of plasma membrane proteins in animal and plant cells.动物和植物细胞中细胞质膜蛋白的磷酸化依赖性运输。
J Integr Plant Biol. 2013 Sep;55(9):789-808. doi: 10.1111/jipb.12096.
引用本文的文献
1
Non-Canonical, Extralysosomal Activities of Lysosomal Peptidases in Physiological and Pathological Conditions: New Clinical Opportunities for Cancer Therapy.溶酶体肽酶在生理和病理条件下的非经典、溶酶体外活性：癌症治疗的新临床机遇
Cells. 2025 Jan 7;14(2):68. doi: 10.3390/cells14020068.
2
The cellular pathways that maintain the quality control and transport of diverse potassium channels.维持多种钾离子通道质量控制和运输的细胞途径。
Biochim Biophys Acta Gene Regul Mech. 2023 Mar;1866(1):194908. doi: 10.1016/j.bbagrm.2023.194908. Epub 2023 Jan 10.
3
Volleying plasma membrane proteins from birth to death: Role of J-domain proteins.从生到死的质膜蛋白转运：J 结构域蛋白的作用
Front Mol Biosci. 2022 Dec 15;9:1072242. doi: 10.3389/fmolb.2022.1072242. eCollection 2022.
4
Intracellular Accumulation of IFN-λ4 Induces ER Stress and Results in Anti-Cirrhotic but Pro-HCV Effects.IFN-λ4 的细胞内积累会诱导内质网应激，导致抗肝硬化但促 HCV 效应。
Front Immunol. 2021 Aug 23;12:692263. doi: 10.3389/fimmu.2021.692263. eCollection 2021.
5
The Protein Translocation Defect of MCT8 Is Rescued by Sodium Phenylbutyrate.苯丁酸钠可挽救MCT8的蛋白质转运缺陷。
Eur Thyroid J. 2020 Sep;9(5):269-280. doi: 10.1159/000507439. Epub 2020 Jul 8.
6
Proline Homeostasis in : How Does the Stress-Responsive Transcription Factor Msn2 Play a Role?脯氨酸稳态：应激反应转录因子Msn2如何发挥作用？
Front Genet. 2020 Apr 28;11:438. doi: 10.3389/fgene.2020.00438. eCollection 2020.
7
Coupling Conjugation and Deconjugation Activities to Achieve Cellular Ubiquitin Dynamics.耦合共轭与去共轭活性以实现细胞内泛素动力学
Trends Biochem Sci. 2020 May;45(5):427-439. doi: 10.1016/j.tibs.2020.01.008. Epub 2020 Feb 28.
8
Protein quality control in the secretory pathway.分泌途径中的蛋白质质量控制。
J Cell Biol. 2019 Oct 7;218(10):3171-3187. doi: 10.1083/jcb.201906047. Epub 2019 Sep 19.
9
Methionine triggers Ppz-mediated dephosphorylation of Art1 to promote cargo-specific endocytosis.蛋氨酸触发 Ppz 介导的 Art1 去磷酸化，促进特定货物的内吞作用。
J Cell Biol. 2019 Mar 4;218(3):977-992. doi: 10.1083/jcb.201712144. Epub 2019 Jan 4.
10
RGS9-2 rescues dopamine D2 receptor levels and signaling in dystonia mouse models.RGS9-2 可挽救亨廷顿舞蹈病小鼠模型中的多巴胺 D2 受体水平和信号转导。
EMBO Mol Med. 2019 Jan;11(1). doi: 10.15252/emmm.201809283.
本文引用的文献
1
Identification of CHIP as a novel causative gene for autosomal recessive cerebellar ataxia.鉴定 CHIP 为常染色体隐性小脑共济失调的一个新的致病基因。
PLoS One. 2013 Dec 2;8(12):e81884. doi: 10.1371/journal.pone.0081884. eCollection 2013.
2
ESCRT regulates surface expression of the Kir2.1 potassium channel.内体分选转运复合体（ESCRT）调节Kir2.1钾通道的表面表达。
Mol Biol Cell. 2014 Jan;25(2):276-89. doi: 10.1091/mbc.E13-07-0394. Epub 2013 Nov 13.
3
Ubiquitination-dependent quality control of hERG K+ channel with acquired and inherited conformational defect at the plasma membrane.在质膜处具有获得性和遗传性构象缺陷的 hERG K+ 通道的泛素化依赖性质量控制。
Mol Biol Cell. 2013 Dec;24(24):3787-804. doi: 10.1091/mbc.E13-07-0417. Epub 2013 Oct 23.
4
Endoplasmic reticulum protein quality control is determined by cooperative interactions between Hsp/c70 protein and the CHIP E3 ligase.内质网蛋白质量控制是由 Hsp/c70 蛋白和 CHIP E3 连接酶之间的协同相互作用决定的。
J Biol Chem. 2013 Oct 25;288(43):31069-79. doi: 10.1074/jbc.M113.479345. Epub 2013 Aug 29.
5
Deubiquitinases sharpen substrate discrimination during membrane protein degradation from the ER.去泛素化酶在 ER 中膜蛋白降解过程中提高底物的特异性。
Cell. 2013 Aug 1;154(3):609-22. doi: 10.1016/j.cell.2013.06.038. Epub 2013 Jul 25.
6
The ART-Rsp5 ubiquitin ligase network comprises a plasma membrane quality control system that protects yeast cells from proteotoxic stress.ART-Rsp5泛素连接酶网络包含一个质膜质量控制系统，该系统可保护酵母细胞免受蛋白毒性应激。
Elife. 2013 Apr 16;2:e00459. doi: 10.7554/eLife.00459.
7
Endoplasmic reticulum stress sensing in the unfolded protein response.内质网应激感应的未折叠蛋白反应。
Cold Spring Harb Perspect Biol. 2013 Mar 1;5(3):a013169. doi: 10.1101/cshperspect.a013169.
8
Quality control and substrate-dependent downregulation of the nutrient transporter Fur4.营养转运蛋白 Fur4 的质量控制和底物依赖性下调。
Traffic. 2013 Apr;14(4):412-27. doi: 10.1111/tra.12039. Epub 2013 Feb 4.
9
Cleaning up: ER-associated degradation to the rescue.清理：ER 相关降解来拯救。
Cell. 2012 Dec 7;151(6):1163-7. doi: 10.1016/j.cell.2012.11.012.
10
The endoplasmic reticulum-associated degradation pathways of budding yeast.出芽酵母内质网相关降解途径。
Cold Spring Harb Perspect Biol. 2012 Dec 1;4(12):a013193. doi: 10.1101/cshperspect.a013193.
Zotero 插件