CaV1.2钙通道：只是为了被调控而存在吗？
CaV1.2 calcium channels: just cut out to be regulated?
作者信息
Groth Rachel D, Tirko Natasha N, Tsien Richard W
机构信息
Centers for Therapeutic Innovation, Pfizer, 1700 Owens Street, San Francisco, CA 94158, USA.
NYU Neuroscience Institute and Department of Neuroscience and Physiology, NYU Langone Medical Center, New York, NY 10016, USA.
出版信息
Neuron. 2014 Jun 4;82(5):939-40. doi: 10.1016/j.neuron.2014.05.030.
Abstract
Tight regulation of calcium entry through the L-type calcium channel CaV1.2 ensures optimal excitation-response coupling. In this issue of Neuron, Michailidis et al. (2014) demonstrate that CaV1.2 activity triggers negative feedback regulation through proteolytic cleavage of the channel within the core of the pore-forming subunit.
摘要
通过L型钙通道CaV1.2对钙内流的严格调控可确保最佳的兴奋-反应偶联。在本期《神经元》杂志中，米凯拉迪斯等人（2014年）证明，CaV1.2的活性通过对形成孔道亚基核心区域内通道的蛋白水解切割来触发负反馈调节。
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