衰老改变了 HIV 大脑前额叶皮层锥体神经元中的电压门控钙通道。
Aging alters voltage-gated calcium channels in prefrontal cortex pyramidal neurons in the HIV brain.
机构信息
Department of Immunology and Microbiology, Rush University Medical Center, Cohn Research Building, Rm.414, 1735 W. Harrison Street, Chicago, IL, 60612, USA.
出版信息
J Neurovirol. 2018 Feb;24(1):113-118. doi: 10.1007/s13365-017-0588-y. Epub 2017 Oct 31.
Abstract
We assessed firing and voltage-gated Ca influx in medial prefrontal cortex (mPFC) pyramidal neurons from older (12 months old) HIV-1 transgenic (Tg) rats. We found that neurons from older Tg rats showed increased firing compared to non-Tg rats, but Ca spikes were unchanged. However, stronger excitatory stimulation was needed to evoke Ca spikes, which was associated with reduced mPFC Ca1.2 L-type Ca channel (L-channel) protein. In contrast, L-channel protein was unaltered in younger (6-7 weeks old) Tg rats, which we previously found had enhanced neuronal Ca influx. These studies demonstrate that aging alters HIV-induced Ca channel dysfunction that affects mPFC activity.
摘要
我们评估了来自老年（12 个月大）HIV-1 转基因（Tg）大鼠的前额皮质（mPFC）中间神经元的放电和电压门控 Ca 内流。我们发现，与非 Tg 大鼠相比，老年 Tg 大鼠的神经元放电增加，但 Ca spikes 不变。然而，需要更强的兴奋性刺激来引发 Ca spikes，这与 mPFC Ca1.2 L 型钙通道（L-通道）蛋白的减少有关。相比之下，我们之前发现年轻（6-7 周龄）Tg 大鼠的神经元 Ca 内流增强，但 L-通道蛋白没有改变。这些研究表明，衰老改变了 HIV 诱导的钙通道功能障碍，从而影响了 mPFC 的活动。
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