Marchegiani Andrea, Fruganti Alessandro, Spaterna Andrea, Cerquetella Matteo, Tambella Adolfo M, Paterson Susan
School of Biosciences and Veterinary Medicine, University of Camerino, Camerino, Italy.
Virtual Vet Derms Ltd. Lakeview, 3 High Birkrigg Park, Stainton, Kendal LA80DY, UK.
Vet Med Int. 2021 Jan 9;2021:6643416. doi: 10.1155/2021/6643416. eCollection 2021.
A single centre, single-blinded, prospective, randomized, controlled clinical study was conducted to evaluate the effectiveness of twice weekly fluorescent light energy therapy (Phovia™) as adjunct to systemic antibiotics in the management of deep pyoderma in dogs. Dogs with clinical lesions consistent with deep pyoderma, positive bacterial culture, and showing neutrophil engulfing bacteria at cytology were included in the study. Assessments were undertaken weekly for 8 weeks and every 2 weeks thereafter until 12 weeks after enrolment. At each visit, lesions were scored and cytology was conducted to determine a neutrophil engulfing bacteria score. All dogs (Groups A and B) were treated with systemic antibiotic twice daily, and Group B received additionally Phovia twice weekly. Median treatment duration was 11.7 weeks for Group A and 5.7 weeks for Group B. After 8 weeks of treatment, the percentage of dogs that achieved clinical resolution was 35.0% and 88.0% for Groups A and B, respectively. Lesion scores showed highly statistically significant difference in favour of Group B from week 3 to 8, and neutrophil engulfing bacteria scores showed statistical difference from week 2 onwards in favour of Group B. These results indicate that Phovia, when used as an adjunct to systemic antibiotics, can accelerate time to clinical resolution in cases of canine deep pyoderma.
开展了一项单中心、单盲、前瞻性、随机对照临床研究，以评估每周两次的荧光光能疗法（Phovia™）作为全身用抗生素辅助治疗犬深部脓皮病的有效性。研究纳入了临床病变符合深部脓皮病、细菌培养阳性且在细胞学检查中显示中性粒细胞吞噬细菌的犬只。在8周内每周进行评估，此后每2周评估一次，直至入组后12周。每次就诊时，对病变进行评分，并进行细胞学检查以确定中性粒细胞吞噬细菌评分。所有犬只（A组和B组）均每天接受两次全身用抗生素治疗，B组额外每周接受两次Phovia治疗。A组的中位治疗持续时间为11.7周，B组为5.7周。治疗8周后，A组和B组实现临床缓解的犬只百分比分别为35.0%和88.0%。病变评分显示，从第3周到第8周，B组有高度统计学显著差异，中性粒细胞吞噬细菌评分从第2周起显示出有利于B组的统计学差异。这些结果表明，Phovia作为全身用抗生素的辅助治疗手段，可加快犬深部脓皮病病例的临床缓解时间。
