Barman Soumik, Koley Hemanta, Nag Dhrubajyoti, Shinoda Sumio, Nair Gopinath Balakrish, Takeda Yoshifumi
National Institute of Cholera and Enteric Diseases, P-33, C.I.T. Road, Scheme XM.
Microbiol Immunol. 2014 Aug;58(8):463-6. doi: 10.1111/1348-0421.12164.
The short- and long-term passive protective efficacy of a mixture of heat-killed cells of six serogroups/serotypes of Shigella strains (Shigella dysenteriae 1, S. flexneri 2a, S. flexneri 3a, S. flexneri 6, S. boydii 4, and S. sonnei) were studied in neonatal mice. Neonatal mice from immunized dams exhibited significant short- and long-term passive protection against individual challenge by each of the six Shigella strains. High IgG and IgA titers against the lipopolysaccharide from each of the six Shigella strains were observed in sera from immunized dams.
研究了六种血清群/血清型志贺氏菌菌株（痢疾志贺氏菌1型、福氏志贺氏菌2a型、福氏志贺氏菌3a型、福氏志贺氏菌6型、鲍氏志贺氏菌4型和宋内志贺氏菌）热灭活细胞混合物对新生小鼠的短期和长期被动保护效力。来自免疫母鼠的新生小鼠对六种志贺氏菌菌株中的每一种进行单独攻击均表现出显著的短期和长期被动保护作用。在免疫母鼠的血清中观察到针对六种志贺氏菌菌株中每一种的脂多糖的高IgG和IgA滴度。
