Zan Minghui, Li Junjie, Luo Shizhong, Ge Zhishen
CAS Key Laboratory of Soft Matter Chemistry, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, Anhui 230026, China.
Chem Commun (Camb). 2014 Jul 25;50(58):7824-7. doi: 10.1039/c4cc03120b.
The polymeric nanogels were constructed via host-guest interactions for dual pH-triggered multistage drug delivery, which showed tumor acidity-triggered nanogel reorganization into smaller nanoparticles for deep tissue penetration, high-efficiency cellular uptake, and intracellular endo-lysosomal pH-responsive drug release.
通过主客体相互作用构建了聚合物纳米凝胶用于双pH触发的多阶段药物递送，其显示出肿瘤酸度触发纳米凝胶重组成更小的纳米颗粒，以实现深部组织渗透、高效细胞摄取和细胞内溶酶体pH响应性药物释放。
