Jiang Nan, Deng Jing-Yu, Liu Yong, Ke Bin, Liu Hong-Gen, Liang Han
Department of Gastric Cancer, National Clinical Research Center of Cancer, Tianjin Medical University Cancer Institute and Hospital , Tianjin , China and.
Biomarkers. 2014 Sep;19(6):444-51. doi: 10.3109/1354750X.2014.926567. Epub 2014 Jun 9.
The objective of this study was to investigate the impact of neutrophil-lymphocyte ratio (NLR) and the platelet-lymphocyte ratio (PLR) on the postoperative complication and long-term outcomes in patients with resectable gastric cancer (GC). A total of 377 patients who underwent curative resection for GC were enrolled. In logistic analysis, PLR (p = 0.09) was independently associated with the incidence of postoperative complication. The results of multivariate survival analysis showed the NLR and PLR were introduced as prognostic factors for operable GC, the NLR may represent a useful prognostic index for the prediction of overall survival (OS) in advanced GC (p = 0.021).
本研究的目的是探讨中性粒细胞与淋巴细胞比值（NLR）和血小板与淋巴细胞比值（PLR）对可切除胃癌（GC）患者术后并发症及长期预后的影响。共纳入377例行GC根治性切除术的患者。在逻辑分析中，PLR（p = 0.09）与术后并发症的发生率独立相关。多因素生存分析结果显示，NLR和PLR被引入作为可手术GC的预后因素，NLR可能是预测晚期GC总生存期（OS）的有用预后指标（p = 0.021）。
