Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, The Netherlands.
Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, The Netherlands.
Semin Cell Dev Biol. 2015 May;41:39-48. doi: 10.1016/j.semcdb.2014.05.016. Epub 2014 Jun 6.
Dendritic cells (DC) are the most potent antigen presenting cells (APC). They comprise a family of different subsets and play an essential role in the induction and regulation of immune responses. Recently, gene expression profiling identified BDCA3(+)CLEC9A(+) DC as a separate human DC subset. This subset was identified in blood, where they represent the smallest population of human DC, as well as in lymphoid and peripheral tissues. This review summarizes the phenotypic, functional and developmental characteristics of BDCA3(+)CLEC9A(+) DC in relation to their mouse equivalents CD8α(+) DC and CD103(+) DC and other human DC subsets. Apart from being potent antigen presenting cells, their specialized functional capacities compared to other human DC subsets, indicate that these BDCA3(+)CLEC9A(+) DC are of major importance in the induction of anti-viral and anti-tumor immunity. Further characterization of their functional properties, developmental pathways and underlying molecular mechanisms may identify target molecules to fully exploit the immune modulatory function of BDCA3(+)CLEC9A(+) DC and potential use of these cells in immunotherapy.
树突状细胞（DC）是最有效的抗原提呈细胞（APC）。它们由不同亚群组成，在诱导和调节免疫反应中发挥着重要作用。最近，基因表达谱分析鉴定出 BDCA3（+）CLEC9A（+）DC 是一种独立的人类 DC 亚群。该亚群在血液中被发现，在血液中它们代表人类 DC 中最小的群体，也存在于淋巴样和外周组织中。这篇综述总结了 BDCA3（+）CLEC9A（+）DC 的表型、功能和发育特征，与它们的小鼠对应物 CD8α（+）DC 和 CD103（+）DC 以及其他人类 DC 亚群进行了比较。除了作为有效的抗原提呈细胞外，与其他人类 DC 亚群相比，它们的特殊功能能力表明，这些 BDCA3（+）CLEC9A（+）DC 在诱导抗病毒和抗肿瘤免疫方面具有重要意义。进一步表征其功能特性、发育途径和潜在的分子机制，可能确定目标分子，以充分利用 BDCA3（+）CLEC9A（+）DC 的免疫调节功能，并潜在地将这些细胞用于免疫治疗。
