MirHashemi Amir Hossein, Afshari Maryam, Alaeddini Mojgan, Etemad-Moghadam Shahroo, Dehpour Ahmadreza, Sheikhzade Sedigheh, Akhoundi Mohammad Sadegh Ahmad
Assistant Professor, Orthodontic Department, Tehran University of Medical Sciences, Tehran, Iran.
Post Graduated Student, Orthodontic Department, Qazvin University of Medical Sciences, Qazvin, Iran.
J Dent (Tehran). 2013 Nov;10(6):532-9. Epub 2013 Nov 30.
Statins are used as cholesterol-lowering drugs by many patients and have been recently shown to affect bone metabolism. The aim of this study was to determine the effect of atorvastatinon on orthodontic tooth movement (OTM) in rats.
Thirty-six adult male Sprague-Dawley rats were randomly divided into three groups of 12 samples each. Group A, served as control with no medication while groups B and C received a daily gavage of carboxymethyl cellulose (CMC) as vehicle and atorvastatin (5 mg/kg) as test substance, respectively. In all three groups, 6mm nickel-titanium closed-coil springs were ligated between the maxillary incisors and first left molars to deliver an initial force of 60g. Tooth movement was measured following sacrifice, 21 days after appliance insertion. Root resorption, PDL width and osteoclast number were histologically evaluated and compared between the groups.
The mean amount of tooth movement was 0.62 mm in group A, 0.59 mm in group B and 0.38 mm in group C. OTM reduction following administration of atorvastatin was statistically significant (p<0.05), but there was no significant difference in the studied histologic variables among the three groups (p>0.05).
According to the results obtained in the current study, atorvastatin appears to reduce tooth movement in rats; however its effect on osteoclasts, especially osteoclastic function, requires further investigation.
许多患者使用他汀类药物作为降胆固醇药物，最近研究表明其会影响骨代谢。本研究旨在确定阿托伐他汀对大鼠正畸牙齿移动（OTM）的影响。
36只成年雄性Sprague-Dawley大鼠随机分为三组，每组12只。A组为未用药的对照组，B组和C组分别每日经口灌胃羧甲基纤维素（CMC）作为赋形剂和阿托伐他汀（5mg/kg）作为受试物。在所有三组中，将6mm镍钛闭合曲弹簧结扎在上颌切牙和左侧第一磨牙之间，施加60g的初始力。在装置植入21天后处死大鼠，测量牙齿移动情况。对牙根吸收、牙周膜宽度和破骨细胞数量进行组织学评估并在组间进行比较。
A组牙齿移动的平均量为0.62mm，B组为0.59mm，C组为0.38mm。服用阿托伐他汀后正畸牙齿移动减少具有统计学意义（p<0.05），但三组间所研究的组织学变量无显著差异（p>0.05）。
根据本研究获得的结果，阿托伐他汀似乎会减少大鼠的牙齿移动；然而其对破骨细胞的影响，尤其是破骨细胞功能，需要进一步研究。
