Mirbagher Leila, Gholamrezaei Ali, Hosseini Naeimeh, Sayed Bonakdar Zahra
Medical Students' Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Poursina Hakim Research Institute, Isfahan, Iran.
Int J Rheum Dis. 2016 Mar;19(3):305-11. doi: 10.1111/1756-185X.12418. Epub 2014 Jun 9.
Sleep quality disturbances are common in patients with systemic lupus erythematosus (SLE). We evaluated sleep quality and its contributors in women with SLE. Also we evaluated the effects of sleep quality disturbance on patients' health-related quality of life (HRQoL).
Sleep quality was assessed in 77 women with SLE (age 36.5 ± 10.1 years) using the Pittsburgh Sleep Quality Index (PSQI). Disease activity and cumulative disease damage were assessed with standard indices. Patients completed the Hospital Anxiety and Depression Scale and LupusQoL. Univariate and multivariate analyses were performed to find contributors of poor sleep quality and association of sleep quality with HRQoL.
Poor sleep quality was present in 44 patients (57.1%). Poor sleepers were older (P = 0.015) and had higher body mass index (P = 0.027) and more severe anxiety (P < 0.001) and depression symptoms (P < 0.007) compared with good sleepers. In the logistic regression model, age (β = 1.16, P = 0.006), disease activity (β = 1.10, P = 0.050), and anxiety/depression composite score (β = 1.16, P = 0.008) were independent contributors of poor sleep quality. Poor sleepers had impaired HRQoL in almost all domains of the LupusQoL than good sleepers (P < 0.05).
Poor sleep quality is common in women with SLE and significantly impairs their HRQoL. Age, disease activity and psychological factors were determinants of sleep quality in our study. Studies with objective sleep measures as well as interventional studies are warranted in this regard.
睡眠质量障碍在系统性红斑狼疮（SLE）患者中很常见。我们评估了SLE女性患者的睡眠质量及其影响因素。此外，我们还评估了睡眠质量障碍对患者健康相关生活质量（HRQoL）的影响。
使用匹兹堡睡眠质量指数（PSQI）对77名SLE女性患者（年龄36.5±10.1岁）的睡眠质量进行评估。用标准指标评估疾病活动度和累积疾病损伤。患者完成医院焦虑抑郁量表和狼疮生活质量量表。进行单因素和多因素分析以找出睡眠质量差的影响因素以及睡眠质量与HRQoL的关联。
44名患者（57.1%）存在睡眠质量差的情况。与睡眠良好者相比，睡眠差的患者年龄更大（P = 0.015）、体重指数更高（P = 0.027），焦虑症状更严重（P < 0.001），抑郁症状更严重（P < 0.007）。在逻辑回归模型中，年龄（β = 1.16，P = 0.006）、疾病活动度（β = 1.10，P = 0.050）和焦虑/抑郁综合评分（β = 1.16，P = 0.008）是睡眠质量差的独立影响因素。与睡眠良好者相比，睡眠差的患者在狼疮生活质量量表的几乎所有领域的HRQoL都受损（P < 0.05）。
睡眠质量差在SLE女性患者中很常见，且显著损害其HRQoL。在我们的研究中，年龄、疾病活动度和心理因素是睡眠质量的决定因素。在这方面有必要进行客观睡眠测量的研究以及干预性研究。
