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海黍甾醇，一种从中国褐藻鼠尾藻中提取的新型甾醇。

Thunberol, a new sterol from the Chinese brown alga Sargassum thunbergii.

作者信息

He Wen-Fei, Yao Li-Gong, Liu Hai-Li, Guo Yue-Wei

机构信息

a School of Pharmacy, Wenzhou Medical University , Wenzhou 325035 , China.

出版信息

J Asian Nat Prod Res. 2014;16(6):685-9. doi: 10.1080/10286020.2014.924511. Epub 2014 Jun 9.

DOI:10.1080/10286020.2014.924511
PMID:24911542
Abstract

A new sterol, named thunberol (1), along with four known analogs, 24-ethylcholesta-4,24(28)-dien-3-one (2), stigmasta-5,28-dien-3β-ol (3), cholesta-5,14-dien-3β-ol (4), and cholesta-5,23-dien-3β,25-diol (5), were isolated from the brown alga Sargassum thunbergii collected from East China Sea. The structures of these metabolites were elucidated on the basis of detailed spectroscopic analysis and by comparison with the literature data. Thunberol (1) exhibited significant inhibitory activity against protein tyrosine phosphatase 1B, a potential drug target for the treatment of Type-II diabetes and obesity, with an IC50 value of 2.24 μg/ml.

摘要

从采自中国东海的褐藻鼠尾藻中分离出一种新的甾醇，命名为扁柏甾醇（1），以及四种已知类似物，24-乙基胆甾-4,24(28)-二烯-3-酮（2）、豆甾-5,28-二烯-3β-醇（3）、胆甾-5,14-二烯-3β-醇（4）和胆甾-5,23-二烯-3β,25-二醇（5）。通过详细的光谱分析并与文献数据比较，阐明了这些代谢产物的结构。扁柏甾醇（1）对蛋白酪氨酸磷酸酶1B表现出显著的抑制活性，蛋白酪氨酸磷酸酶1B是治疗II型糖尿病和肥胖症的潜在药物靶点，其IC50值为2.24μg/ml。

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