University of Hohenheim, Institute of Food Chemistry, Garbenstraße 28, 70599 Stuttgart, Germany.
State Laboratory Schleswig-Holstein (LSH), Department of Residue and Contamination Analysis, 24537 Neumünster, Germany.
Sci Total Environ. 2014 Aug 15;490:994-1001. doi: 10.1016/j.scitotenv.2014.05.053. Epub 2014 Jun 7.
Different halogenated natural products (HNPs) have been reported to occur in marine wildlife, particularly from regions with comparably little contamination with anthropogenic pollutants. The North Sea and the Baltic Sea have been known as a marine site heavily polluted with organohalogen compounds, and especially with polychlorinated biphenyls (PCBs). In this study we wished to determine the current abundance of HNPs in comparison with 2,2',4,4',5,5'-hexachlorobiphenyl (PCB 153), i.e. the major PCB congener in marine biota. For this purpose, forty blue mussels (Mytilus edulis) and oysters (Crassostrea gigas) from seven sites were analyzed on HNPs and PCB 153. Most of the samples contained HNPs in the form of polyhalogenated 1'-methyl-1,2'-bipyrroles (PMBPs including Q1) and the mixed halogenated compound MHC-1. In addition we determined several polyhalogenated 1,1'-dimethyl-2,2'-bipyrroles (PDBPs), 2,3,4,5-tetrabromo-N-methylpyrrole and several novel homologs, as well as polybrominated N-methylindoles. The occurrence of these HNP groups were considerably different in the samples from different regions with varying sum concentrations up to 1930 μg/kg lipids in blue mussels from Heligoland (North Sea) and much lower concentrations in samples from the Baltic Sea (up to 13 μg/kg lipids). The concentrations of HNPs varied by two orders of magnitude, compared to a factor of 10 for PCB 153, suggesting that HNPs are more spatially (and perhaps temporally) variant than POPs. In the North Sea region Heligoland, HNPs were more abundant than PCB 153.
不同的卤化天然产物（HNPs）已被报道存在于海洋野生动物中，尤其是在受人为污染物污染程度相对较低的地区。北海和波罗的海一直被认为是受有机卤代化合物污染严重的海洋区域，特别是多氯联苯（PCBs）。在这项研究中，我们希望确定与 2,2',4,4',5,5'-六氯联苯（PCB 153）相比，HNPs 的当前丰度，即海洋生物群中主要的 PCB 同系物。为此，我们分析了来自七个地点的 40 只贻贝（Mytilus edulis）和牡蛎（Crassostrea gigas）中的 HNPs 和 PCB 153。大多数样品以多卤代 1'-甲基-1,2'-联吡咯（PMBPs 包括 Q1）和混合卤代化合物 MHC-1 的形式存在 HNPs。此外，我们还测定了几种多卤代 1,1'-二甲基-2,2'-联吡咯（PDBPs）、2,3,4,5-四溴-N-甲基吡咯和几种新的同系物，以及多溴化 N-甲基吲哚。这些 HNP 组在来自不同地区的样品中的出现情况有很大差异，总浓度变化范围很大，在来自北海的黑尔戈兰岛（Heligoland）的贻贝中高达 1930μg/kg 脂质，而在波罗的海的样品中浓度要低得多（高达 13μg/kg 脂质）。与 PCB 153 的 10 倍相比，HNPs 的浓度变化幅度大两个数量级，这表明 HNPs 比 POPs 在空间（也许是时间）上的变化更大。在北海地区的黑尔戈兰岛，HNPs 的丰度高于 PCB 153。
