Chua John Jia En
Department of Neurobiology, Max-Planck-Institute for Biophysical Chemistry, Am Fassberg 11, 37077, Göttingen, Germany,
Cell Mol Life Sci. 2014 Oct;71(20):3903-16. doi: 10.1007/s00018-014-1657-5. Epub 2014 Jun 10.
The release of neurotransmitters from synaptic vesicles exocytosing at presynaptic nerve terminals is a critical event in the initiation of synaptic transmission. This event occurs at specialized sites known as active zones. The task of faithfully executing various steps in the process is undertaken by careful orchestration of overlapping sets of molecular nano-machineries upon a core macromolecular scaffold situated at active zones. However, their composition remains incompletely elucidated. This review provides an overview of the role of the active zone in mediating neurotransmitter release and summarizes the recent progress using neuroproteomic approaches to decipher their composition. Key proteins of these nano-machineries are highlighted.
神经递质从突触前神经末梢处胞吐的突触小泡中释放，是突触传递起始过程中的一个关键事件。这一事件发生在被称为活性区的特化部位。该过程中各个步骤的精确执行任务，是由位于活性区的核心大分子支架上重叠的分子纳米机器集合精心编排完成的。然而，它们的组成仍未完全阐明。本综述概述了活性区在介导神经递质释放中的作用，并总结了使用神经蛋白质组学方法破译其组成的最新进展。重点介绍了这些纳米机器的关键蛋白质。
