葡萄糖-6-磷酸脱氢酶状态与接受单剂量伯氨喹的恶性疟原虫感染非洲儿童溶血风险
Glucose-6-phosphate dehydrogenase status and risk of hemolysis in Plasmodium falciparum-infected African children receiving single-dose primaquine.
作者信息
Eziefula Alice C, Pett Helmi, Grignard Lynn, Opus Salome, Kiggundu Moses, Kamya Moses R, Yeung Shunmay, Staedke Sarah G, Bousema Teun, Drakeley Chris
机构信息
Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, The Netherlands.
出版信息
Antimicrob Agents Chemother. 2014 Aug;58(8):4971-3. doi: 10.1128/AAC.02889-14. Epub 2014 Jun 9.
Abstract
Glucose-6-phosphate dehydrogenase (G6PD) enzyme function and genotype were determined in Ugandan children with uncomplicated falciparum malaria enrolled in a primaquine trial after exclusion of severe G6PD deficiency by fluorescent spot test. G6PD A- heterozygotes and hemizygotes/homozygotes experienced dose-dependent lower hemoglobin concentrations after treatment. No severe anemia was observed.
摘要
在一项伯氨喹试验中，对乌干达患有单纯性恶性疟原虫疟疾的儿童进行了葡萄糖-6-磷酸脱氢酶（G6PD）酶功能和基因型测定，这些儿童在通过荧光斑点试验排除严重G6PD缺乏症后入选。G6PD A-杂合子以及半合子/纯合子在治疗后血红蛋白浓度出现剂量依赖性降低。未观察到严重贫血。
相似文献
1
Glucose-6-phosphate dehydrogenase status and risk of hemolysis in Plasmodium falciparum-infected African children receiving single-dose primaquine.葡萄糖-6-磷酸脱氢酶状态与接受单剂量伯氨喹的恶性疟原虫感染非洲儿童溶血风险
Antimicrob Agents Chemother. 2014 Aug;58(8):4971-3. doi: 10.1128/AAC.02889-14. Epub 2014 Jun 9.
2
Safety of age-dosed, single low-dose primaquine in children with glucose-6-phosphate dehydrogenase deficiency who are infected with Plasmodium falciparum in Uganda and the Democratic Republic of the Congo: a randomised, double-blind, placebo-controlled, non-inferiority trial.乌干达和刚果民主共和国感染恶性疟原虫的葡萄糖-6-磷酸脱氢酶缺乏儿童中按年龄给药的单次低剂量伯氨喹安全性：一项随机、双盲、安慰剂对照、非劣效性试验
Lancet Infect Dis. 2023 Apr;23(4):471-483. doi: 10.1016/S1473-3099(22)00658-2. Epub 2022 Nov 30.
3
Single Low Dose Primaquine (0.25 mg/kg) Does Not Cause Clinically Significant Haemolysis in G6PD Deficient Subjects.单次低剂量伯氨喹（0.25毫克/千克）不会在葡萄糖-6-磷酸脱氢酶（G6PD）缺乏的受试者中引起具有临床意义的溶血。
PLoS One. 2016 Mar 24;11(3):e0151898. doi: 10.1371/journal.pone.0151898. eCollection 2016.
4
The effect of single low-dose primaquine treatment for uncomplicated Plasmodium falciparum malaria on haemoglobin levels in Ethiopia: a longitudinal cohort study.单剂低剂量磷酸萘酚喹治疗无并发症恶性疟原虫疟疾对埃塞俄比亚血红蛋白水平的影响：一项纵向队列研究。
Malar J. 2024 Jul 12;23(1):208. doi: 10.1186/s12936-024-05021-x.
5
In Tanzania, hemolysis after a single dose of primaquine coadministered with an artemisinin is not restricted to glucose-6-phosphate dehydrogenase-deficient (G6PD A-) individuals.在坦桑尼亚，与青蒿素联合使用一剂伯氨喹后发生的溶血并不仅限于葡萄糖-6-磷酸脱氢酶缺乏症（G6PD A-）个体。
Antimicrob Agents Chemother. 2010 May;54(5):1762-8. doi: 10.1128/AAC.01135-09. Epub 2010 Mar 1.
6
Factors affecting haemoglobin dynamics in African children with acute uncomplicated Plasmodium falciparum malaria treated with single low-dose primaquine or placebo.影响用单剂低剂量伯氨喹或安慰剂治疗的无并发症急性恶性疟原虫疟疾非洲儿童血红蛋白动态变化的因素。
BMC Med. 2023 Oct 20;21(1):397. doi: 10.1186/s12916-023-03105-0.
7
Haemolysis in G6PD Heterozygous Females Treated with Primaquine for Plasmodium vivax Malaria: A Nested Cohort in a Trial of Radical Curative Regimens.用伯氨喹治疗间日疟原虫疟疾的G6PD杂合子女性中的溶血：根治性治疗方案试验中的嵌套队列研究。
PLoS Med. 2017 Feb 7;14(2):e1002224. doi: 10.1371/journal.pmed.1002224. eCollection 2017 Feb.
8
Model-based assessment of the safety of community interventions with primaquine in sub-Saharan Africa.基于模型的评估：在撒哈拉以南非洲地区使用伯氨喹进行社区干预的安全性。
Parasit Vectors. 2021 Oct 9;14(1):524. doi: 10.1186/s13071-021-05034-4.
9
The use of primaquine in malaria infected patients with red cell glucose-6-phosphate dehydrogenase (G6PD) deficiency in Myanmar.缅甸疟疾病患中红细胞葡萄糖-6-磷酸脱氢酶（G6PD）缺乏症患者使用伯氨喹的情况。
Southeast Asian J Trop Med Public Health. 1994 Dec;25(4):710-3.
10
Polymorphisms and the Safety and Gametocytocidal Activity of Single-Dose Primaquine for Plasmodium falciparum.多态性与单次剂量磷酸萘酚喹治疗恶性疟原虫的安全性和配子体杀伤活性
Antimicrob Agents Chemother. 2019 Sep 23;63(10). doi: 10.1128/AAC.00538-19. Print 2019 Oct.
引用本文的文献
1
Use of trimethoprim- sulfamethoxazole for treating in a patient with glucose-6-phosphate dehydrogenase deficiency: a case report.在葡萄糖-6-磷酸脱氢酶缺乏症患者中使用甲氧苄啶-磺胺甲恶唑治疗：一例病例报告。
Front Med (Lausanne). 2024 Sep 10;11:1443645. doi: 10.3389/fmed.2024.1443645. eCollection 2024.
2
Prevalence of G6PD deficiency and submicroscopic malaria parasites carriage in malaria hotspot area in Northwest, Tanzania.坦桑尼亚西北部疟疾热点地区葡萄糖-6-磷酸脱氢酶（G6PD）缺乏症和亚临床疟原虫携带率。
Malar J. 2023 Dec 7;22(1):372. doi: 10.1186/s12936-023-04801-1.
3
Rapid and Specific Action of Methylene Blue against Transmission Stages.亚甲蓝对传播阶段的快速且特异性作用
Pharmaceutics. 2022 Dec 14;14(12):2794. doi: 10.3390/pharmaceutics14122794.
4
The medication for pneumocystis pneumonia with glucose-6-phosphate dehydrogenase deficiency patients.葡萄糖-6-磷酸脱氢酶缺乏症患者的肺孢子菌肺炎用药。
Front Pharmacol. 2022 Sep 7;13:957376. doi: 10.3389/fphar.2022.957376. eCollection 2022.
5
Model-based assessment of the safety of community interventions with primaquine in sub-Saharan Africa.基于模型的评估：在撒哈拉以南非洲地区使用伯氨喹进行社区干预的安全性。
Parasit Vectors. 2021 Oct 9;14(1):524. doi: 10.1186/s13071-021-05034-4.
6
Current investigations on clinical pharmacology and therapeutics of Glucose-6-phosphate dehydrogenase deficiency.葡萄糖-6-磷酸脱氢酶缺乏症的临床药理学和治疗学的当前研究。
Pharmacol Ther. 2021 Jun;222:107788. doi: 10.1016/j.pharmthera.2020.107788. Epub 2020 Dec 14.
7
Anemia in preschool children from Angola: a review of the evidence.安哥拉学龄前儿童贫血症：证据综述
Porto Biomed J. 2020 Feb 11;5(1):e60. doi: 10.1097/j.pbj.0000000000000060. eCollection 2020 Jan-Feb.
8
Iron deficiency anaemia among 6-to-36-month children from northern Angola.安哥拉北部6至36个月儿童的缺铁性贫血情况。
BMC Pediatr. 2020 Jun 17;20(1):298. doi: 10.1186/s12887-020-02185-8.
9
Safety Considerations for Malaria Volunteer Infection Studies: A Mini-Review.疟疾志愿者感染研究的安全性考虑：小型综述。
Am J Trop Med Hyg. 2020 May;102(5):934-939. doi: 10.4269/ajtmh.19-0351.
10
Safety and tolerability of single low-dose primaquine in a low-intensity transmission area in South Africa: an open-label, randomized controlled trial.南非低强度传播地区单次低剂量磷酸氯喹的安全性和耐受性：一项开放标签、随机对照试验。
Malar J. 2019 Jun 24;18(1):209. doi: 10.1186/s12936-019-2841-8.
本文引用的文献
1
Single dose primaquine for clearance of Plasmodium falciparum gametocytes in children with uncomplicated malaria in Uganda: a randomised, controlled, double-blind, dose-ranging trial.单次剂量磷酸萘酚喹清除乌干达无并发症疟疾儿童疟原虫配子体：一项随机、对照、双盲、剂量范围试验。
Lancet Infect Dis. 2014 Feb;14(2):130-9. doi: 10.1016/S1473-3099(13)70268-8. Epub 2013 Nov 13.
2
G6PD testing in support of treatment and elimination of malaria: recommendations for evaluation of G6PD tests.支持疟疾治疗和消除的 G6PD 检测：G6PD 检测评估的建议。
Malar J. 2013 Nov 4;12:391. doi: 10.1186/1475-2875-12-391.
3
Primaquine failure and cytochrome P-450 2D6 in Plasmodium vivax malaria.间日疟原虫疟疾中的伯氨喹失效与细胞色素P-450 2D6
N Engl J Med. 2013 Oct 3;369(14):1381-2. doi: 10.1056/NEJMc1301936.
4
Study protocol for a randomised controlled double-blinded trial of the dose-dependent efficacy and safety of primaquine for clearance of gametocytes in children with uncomplicated falciparum malaria in Uganda.一项在乌干达患有无并发症恶性疟原虫疟疾的儿童中评估氯喹剂量依赖性清除配子体疗效和安全性的随机对照双盲试验研究方案。
BMJ Open. 2013 Mar 26;3(3):e002759. doi: 10.1136/bmjopen-2013-002759.
5
Primaquine to prevent transmission of falciparum malaria.伯氨喹预防恶性疟传播。
Lancet Infect Dis. 2013 Feb;13(2):175-81. doi: 10.1016/S1473-3099(12)70198-6. Epub 2012 Nov 23.
6
In Tanzania, hemolysis after a single dose of primaquine coadministered with an artemisinin is not restricted to glucose-6-phosphate dehydrogenase-deficient (G6PD A-) individuals.在坦桑尼亚，与青蒿素联合使用一剂伯氨喹后发生的溶血并不仅限于葡萄糖-6-磷酸脱氢酶缺乏症（G6PD A-）个体。
Antimicrob Agents Chemother. 2010 May;54(5):1762-8. doi: 10.1128/AAC.01135-09. Epub 2010 Mar 1.
7
Chlorproguanil-dapsone-artesunate versus artemether-lumefantrine: a randomized, double-blind phase III trial in African children and adolescents with uncomplicated Plasmodium falciparum malaria.氯喹-氨苯砜-青蒿琥酯与蒿甲醚-本芴醇：一项在非洲无并发症恶性疟原虫疟疾儿童和青少年中开展的随机、双盲 III 期临床试验。
PLoS One. 2009 Aug 19;4(8):e6682. doi: 10.1371/journal.pone.0006682.
8
High risk of severe anaemia after chlorproguanil-dapsone+artesunate antimalarial treatment in patients with G6PD (A-) deficiency.葡萄糖-6-磷酸脱氢酶（A-）缺乏症患者接受氯胍-氨苯砜+青蒿琥酯抗疟治疗后发生严重贫血的风险较高。
PLoS One. 2008;3(12):e4031. doi: 10.1371/journal.pone.0004031. Epub 2008 Dec 29.
9
The normal human female as a mosaic of X-chromosome activity: studies using the gene for C-6-PD-deficiency as a marker.作为X染色体活性嵌合体的正常人类女性：以C-6-PD缺乏症基因作为标记的研究
Proc Natl Acad Sci U S A. 1962 Jan 15;48(1):9-16. doi: 10.1073/pnas.48.1.9.
10
Mitigation of the haemolytic effect of primaquine and enhancement of its action against exoerythrocytic forms of the Chesson strain of Piasmodium vivax by intermittent regimens of drug administration: a preliminary report.通过间歇性给药方案减轻伯氨喹的溶血作用并增强其对间日疟原虫切森株红细胞外期的作用：初步报告
Bull World Health Organ. 1960;22(6):621-31.
Zotero 插件