Tishevskaya N V, Zakharov Yu M, Golubotovskii E V, Kolesnikov O L, Trofimova N V, Arkhipenko Yu V, Sazontova T G
Chelyabinsk State Medical Academy, Chelyabinsk, Russia,
Bull Exp Biol Med. 2014 May;157(1):49-51. doi: 10.1007/s10517-014-2489-x. Epub 2014 Jun 10.
The effects of fullerenol C60(OH)24 in doses of 0.1-100 μg/ml on erythropoiesis were studied in the culture of erythroblastic islets of the bone marrow. Fullerenol in concentrations of 10 and 100 μg/ml had negative effects on the development of erythroid tissue: it inhibits proliferation of erythroid cells, delays erythroblast maturation, decelerates recruitment of erythroid CFU to differentiation, and suppresses repeated involvement of macrophages in erythroblastic islets.
研究了浓度为0.1 - 100μg/ml的富勒醇C60(OH)24对骨髓成红细胞岛培养物中红细胞生成的影响。浓度为10μg/ml和100μg/ml的富勒醇对红系组织的发育有负面影响：它抑制红系细胞增殖，延迟成红细胞成熟，减缓红系集落形成单位向分化的募集，并抑制巨噬细胞反复参与成红细胞岛。
