Emergency Department, Pôle Sino-Français de Recherches en Sciences du Vivant et Génomique, Shanghai Ruijin Hospital, Shanghai 200025, China.
Institute for Research on Cancer and Aging, Nice (IRCAN), Nice University, CNRS UMR7284/INSERM U1081, Faculty of Medicine, Nice 06107, France.
Nat Rev Genet. 2014 Jul;15(7):491-503. doi: 10.1038/nrg3743. Epub 2014 Jun 10.
Telomeres protect chromosome ends from degradation and inappropriate DNA damage response activation through their association with specific factors. Interestingly, these telomeric factors are able to localize outside telomeric regions, where they can regulate the transcription of genes involved in metabolism, immunity and differentiation. These findings delineate a signalling pathway by which telomeric changes control the ability of their associated factors to regulate transcription. This mechanism is expected to enable a greater diversity of cellular responses that are adapted to specific cell types and telomeric changes, and may therefore represent a pivotal aspect of development, ageing and telomere-mediated diseases.
端粒通过与特定因子的结合，保护染色体末端免受降解和不当的 DNA 损伤反应激活。有趣的是，这些端粒因子能够定位于端粒区域之外，在那里它们可以调节参与代谢、免疫和分化的基因的转录。这些发现描绘了一条信号通路，通过该通路，端粒变化控制与其相关因子调节转录的能力。这种机制有望使细胞产生更多适应特定细胞类型和端粒变化的多样化反应，因此可能代表着发育、衰老和端粒介导疾病的一个关键方面。
