Mehta T, Fontaine K R, Keith S W, Bangalore S S, de los Campos G, Bartolucci A, Pajewski N M, Allison D B
Department of Biostatistics, Office of Energetics and Nutrition Obesity Research Center, University of Alabama at Birmingham, Birmingham, AL, USA.
Obes Rev. 2014 Aug;15(8):619-29. doi: 10.1111/obr.12191. Epub 2014 Jun 9.
We evaluated whether the obesity-associated years of life lost (YLL) have decreased over calendar time. We implemented a meta-analysis including only studies with two or more serial body mass index (BMI) assessments at different calendar years. For each BMI category (normal weight: BMI 18.5 to <25 [reference]; overweight: BMI 25 to <30; grade 1 obesity: BMI 30 to <35; and grade 2-3 obesity: BMI ≥ 35), we estimated the YLL change between 1970 and 1990. Because of low sample sizes for African-American, results are reported on Caucasian. Among men aged ≤60 years YLL for grade 1 obesity increased by 0.72 years (P < 0.001) and by 1.02 years (P = 0.01) for grade 2-3 obesity. For men aged >60, YLL for grade 1 obesity decreased by 1.02 years (P < 0.001) and increased by 0.63 years for grade 2-3 obesity (P = 0.63). Among women aged ≤60, YLL for grade 1 obesity decreased by 4.21 years (P < 0.001) and by 4.97 years (P < 0.001) for grade 2-3 obesity. In women aged >60, YLL for grade 1 obesity decreased by 3.98 years (P < 0.001) and by 2.64 years (P = 0.001) for grade 2-3 obesity. Grade 1 obesity's association with decreased longevity has reduced for older Caucasian men. For Caucasian women, there is evidence of a decline in the obesity YLL association across all ages.
我们评估了肥胖相关的寿命损失年数（YLL）是否随时间推移而减少。我们进行了一项荟萃分析，仅纳入在不同年份进行过两次或更多次连续体重指数（BMI）评估的研究。对于每个BMI类别（正常体重：BMI 18.5至<25[参考值]；超重：BMI 25至<30；1级肥胖：BMI 30至<35；2 - 3级肥胖：BMI≥35），我们估计了1970年至1990年期间YLL的变化。由于非裔美国人的样本量较低，结果按白种人报告。在60岁及以下的男性中，1级肥胖的YLL增加了0.72年（P<0.001），2 - 3级肥胖的YLL增加了1.02年（P = 0.01）。对于60岁以上的男性，1级肥胖的YLL减少了1.02年（P<0.001），2 - 3级肥胖的YLL增加了0.63年（P = 0.63）。在60岁及以下的女性中，1级肥胖的YLL减少了4.21年（P<0.001），2 - 3级肥胖的YLL减少了4.97年（P<0.001）。在60岁以上的女性中，1级肥胖的YLL减少了3.98年（P<0.001），2 - 3级肥胖的YLL减少了2.64年（P = 0.001）。对于老年白种男性，1级肥胖与寿命缩短之间的关联有所减弱。对于白种女性，有证据表明在所有年龄段肥胖与YLL之间的关联都在下降。
