School of Public Health, University of Alabama at Birmingham, Birmingham.
School of Public Health, University of Alabama at Birmingham, Birmingham.
Ann Epidemiol. 2023 Jun;82:26-32. doi: 10.1016/j.annepidem.2023.03.010. Epub 2023 Apr 2.
The strength of the association between obesity and mortality rate (MR) varies by body mass index (BMI) and sociodemographic groups. We test the hypothesis that the association between obesity and MR varies, in part, due to the moderating effect of parental BMI and birth weight.
Data come from the 1958 National Child Development Study, an ongoing longitudinal dataset initiated in 1958 with baseline measures of birth weight from 18,059 infants born in Great Britain over 1 week. We tested whether the association between BMI and MR was moderated by parental BMI and birth weight using generalized additive proportional hazards models.
The association between adult BMI and MR was moderated by birth weight and maternal BMI, such that the association between BMI and MR was weaker among individuals with a higher birth weight (P = .0148) and stronger among individuals born to mothers with a higher BMI (P = .032). At any given level of BMI approximately greater than 25, individuals with low birth weight or born to mothers with a higher BMI, had a higher MR. Paternal BMI did not significantly modify the relationship between BMI and MR (P = .5168).
Results suggest that the relationship between obesity and MR is modified by birth weight and maternal BMI.
肥胖与死亡率（MR）之间的关联强度因体重指数（BMI）和社会人口统计学群体而异。我们检验了这样一个假设，即肥胖与 MR 之间的关联在一定程度上是由于父母 BMI 和出生体重的调节作用而发生变化的。
数据来自于 1958 年英国全国儿童发展研究，这是一项始于 1958 年的持续纵向数据集，其基线数据包括来自英国在一周内出生的 18059 名婴儿的出生体重。我们使用广义加性比例风险模型来检验 BMI 和 MR 之间的关联是否受到父母 BMI 和出生体重的调节。
成人 BMI 与 MR 之间的关联受到出生体重和母亲 BMI 的调节，例如，在出生体重较高的个体中（P=0.0148），BMI 与 MR 之间的关联较弱，而在母亲 BMI 较高的个体中（P=0.032），这种关联较强。在任何给定的 BMI 水平（约大于 25），出生体重较低或母亲 BMI 较高的个体，其 MR 较高。父亲 BMI 并没有显著改变 BMI 和 MR 之间的关系（P=0.5168）。
结果表明，肥胖与 MR 之间的关系受到出生体重和母亲 BMI 的调节。
