Cancer and Inflammation Program, National Cancer Institute, Frederick, MD 21702, USA.
Cancer and Inflammation Program, National Cancer Institute, Frederick, MD 21702, USA; Leidos Biomedical Research, Inc., Frederick, MD 21701, USA.
Cell Host Microbe. 2014 Mar 12;15(3):295-305. doi: 10.1016/j.chom.2014.02.003.
Both microbes and tumors activate innate resistance, tissue repair, and adaptive immunity. Unlike acute infection, tumor growth is initially unapparent; however, inflammation and immunity affect all phases of tumor growth from initiation to progression and dissemination. Here, we discuss the shared features involved in the immune response to infection and cancer including modulation by commensal microbiota, reactive hematopoiesis, chronic immune responses and regulatory mechanisms to prevent collateral tissue damage. This comparative analysis of immunity to infection and cancer furthers our understanding of the basic mechanisms underlying innate resistance and adaptive immunity and their translational application to the design of new therapeutic approaches.
微生物和肿瘤均可激活固有免疫、组织修复和适应性免疫。与急性感染不同，肿瘤生长起初并不明显；然而，炎症和免疫会影响肿瘤生长的各个阶段，从起始到进展和扩散。在这里，我们讨论了感染和癌症免疫反应所涉及的共同特征，包括共生微生物群的调节、反应性造血、慢性免疫反应和防止继发组织损伤的调节机制。这种对感染和癌症免疫的比较分析增进了我们对固有抵抗和适应性免疫基本机制的理解，并将其转化应用于新治疗方法的设计。
