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一名免疫功能正常的重症登革热患者发生侵袭性肺曲霉病。

Invasive pulmonary aspergillosis in an immunocompetent patient with severe dengue fever.

作者信息

Nasa Prashant, Yadav Rohit, Nagrani S K, Raina Sanjay, Gupta Ankur, Jain Shakti

机构信息

Consultant and Coordinator, Department of Critical Care Medicine, Max Superspeciality Hospital, Shalimar Bagh, New Delhi, India.

Attending Consultant, Department of Critical Care Medicine, Max Superspeciality Hospital, Shalimar Bagh, New Delhi, India.

出版信息

Indian J Crit Care Med. 2014 May;18(5):323-5. doi: 10.4103/0972-5229.132505.

DOI:10.4103/0972-5229.132505
PMID:24914263
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4047696/
Abstract

We report a case of a 65-year-old female diagnosed with sever dengue fever. She started showing recovery from dengue fever with medical management. On day 6 of admission, she had leukocytosis, altered mental sensorium, and hemoptysis. Chest tomography showed air space consolidation with multiple nodules in the left upper and middle lobe sputum and bronchoalveolar lavage cultures were positive for Aspergillus flavus. The patient showed improvement with voriconazole and therapy was continued for 6 weeks.

摘要

我们报告一例65岁女性被诊断为重症登革热的病例。经过药物治疗,她开始从登革热中康复。入院第6天,她出现白细胞增多、意识改变和咯血。胸部断层扫描显示左上叶和中叶有气腔实变并伴有多个结节,痰液和支气管肺泡灌洗培养曲霉菌呈阳性。患者使用伏立康唑后病情好转,治疗持续了6周。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc6d/4047696/d282380b6df1/IJCCM-18-323-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc6d/4047696/9987325bcc3d/IJCCM-18-323-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc6d/4047696/ee32592ef271/IJCCM-18-323-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc6d/4047696/d282380b6df1/IJCCM-18-323-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc6d/4047696/9987325bcc3d/IJCCM-18-323-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc6d/4047696/ee32592ef271/IJCCM-18-323-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc6d/4047696/d282380b6df1/IJCCM-18-323-g003.jpg

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本文引用的文献

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Epidemiol Infect. 2012 Oct;140(10):1848-52. doi: 10.1017/S0950268811002603. Epub 2011 Dec 8.
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Pulmonary aspergillosis: a clinical review.肺曲霉病:临床综述。
Eur Respir Rev. 2011 Sep 1;20(121):156-74. doi: 10.1183/09059180.00001011.
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[Two cases of successfully treated invasive pulmonary aspergillosis following influenza virus infection].
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Indian J Crit Care Med. 2014 Sep;18(9):637-8. doi: 10.4103/0972-5229.140158.
[两例流感病毒感染后侵袭性肺曲霉病成功治疗的病例]
Nihon Kokyuki Gakkai Zasshi. 2007 Apr;45(4):349-55.
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Crit Care. 2006;10(2):132. doi: 10.1186/cc4860.
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Clinical relevance of Aspergillus isolation from respiratory tract samples in critically ill patients.重症患者呼吸道样本中分离出曲霉菌的临床相关性。
Crit Care. 2006 Feb;10(1):R31. doi: 10.1186/cc4823.
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