Zhang Lin, Cheng Jian, Fan Xiao-Ming
Lin Zhang, Jian Cheng, Xiao-Ming Fan, Department of Gastroenterology and Hepatology, Jinshan Hospital of Fudan University, Shanghai 201508, China.
World J Gastroenterol. 2014 May 21;20(19):5818-25. doi: 10.3748/wjg.v20.i19.5818.
Defects in intestinal barrier function characterized by an increase in intestinal permeability contribute to intestinal inflammation. Growing evidence has shown that an increase in intestinal permeability has a pathogenic role in diseases such as inflammatory bowel disease (IBD) and celiac disease, and functional bowel disorders such as irritable bowel syndrome. Therefore, clarification of the inflammatory responses, the defense pathway and the corresponding regulatory system is essential and may lead to the development of new therapies. MicroRNAs (miRNAs) are small (19-22 nt) noncoding RNA molecules that regulate genes at the post-transcriptional level by base-pairing to specific messenger RNAs for degradation to repress translation. Recent studies suggested that miRNAs are important in the immune response and mediate a critical role in multiple immune response-related disorders. Based on these discoveries, attention has been focused on understanding the role of miRNAs in regulating intestinal barrier dysfunction, especially in IBD. Here, we provide a review of the most recent state-of-the-art research on miRNAs in intestinal barrier dysfunction.
以肠道通透性增加为特征的肠道屏障功能缺陷会导致肠道炎症。越来越多的证据表明，肠道通透性增加在诸如炎症性肠病（IBD）、乳糜泻等疾病以及诸如肠易激综合征等功能性肠病中具有致病作用。因此，阐明炎症反应、防御途径及相应的调节系统至关重要，且可能会带来新疗法的开发。微小RNA（miRNA）是小（19 - 22个核苷酸）的非编码RNA分子，其通过与特定信使RNA碱基配对以进行降解来抑制翻译，从而在转录后水平调控基因。最近的研究表明，miRNA在免疫反应中很重要，并在多种免疫反应相关疾病中发挥关键作用。基于这些发现，人们已将注意力集中在了解miRNA在调节肠道屏障功能障碍中的作用，尤其是在IBD中。在此，我们对miRNA在肠道屏障功能障碍方面的最新前沿研究进行综述。
