Division of Gastroenterology and Hepatology, Mayo Clinic, 200 First St. S.W., Rochester, MN, 55905, USA.
Clinical Enteric Neuroscience Translational and Epidemiological Research (CENTER), Mayo Clinic, Rochester, MN, USA.
Dig Dis Sci. 2023 Dec;68(12):4306-4320. doi: 10.1007/s10620-023-08122-w. Epub 2023 Sep 29.
The intestinal barrier is composed of several essential elements including luminal enzymes, bile acids, water layer, epithelial layer, and enterocyte layer. It acts as a dynamic interface between the luminal contents of food, commensal and pathogenic bacteria, and the gastrointestinal tract. The role of barrier dysfunction is of significant research interest in the development and targeted treatment of chronic inflammatory gastrointestinal conditions, such as inflammatory bowel disease. This review aims to examine the role of intestinal barrier dysfunction in the development of inflammatory bowel disease, the pathophysiology of increased barrier permeability in inflammatory bowel disease, and to explore potential treatment targets and clinical applications.
肠道屏障由几个重要的元素组成，包括腔内酶、胆汁酸、水层、上皮层和肠细胞层。它作为食物、共生菌和致病菌与胃肠道之间的腔内内容物的动态界面。屏障功能障碍的作用在慢性炎症性胃肠道疾病（如炎症性肠病）的发展和靶向治疗中具有重要的研究意义。本综述旨在探讨肠道屏障功能障碍在炎症性肠病发展中的作用、炎症性肠病中屏障通透性增加的病理生理学，以及探索潜在的治疗靶点和临床应用。
