MacNair Alistair J, Tran Ming-Ming, Nelson Jennifer E, Sloan G Usherwood, Ironmonger Alan, Thomas Stephen P
School of Chemistry, University of Edinburgh, Joseph Black Building, West Mains Road, Edinburgh EH9 3JJ, UK.
Org Biomol Chem. 2014 Jul 28;12(28):5082-8. doi: 10.1039/c4ob00945b.
An operationally simple and environmentally benign formal hydrogenation protocol has been developed using highly abundant iron(iii) salts and an inexpensive, bench stable, stoichiometric reductant, NaBH4, in ethanol, under ambient conditions. This reaction has been applied to the reduction of terminal alkenes (22 examples, up to 95% yield) and nitro-groups (26 examples, up to 95% yield). Deuterium labelling studies indicate that this reaction proceeds via an ionic rather than radical mechanism.
已开发出一种操作简单且环境友好的形式氢化方案，该方案使用高丰度的铁（III）盐和一种廉价、在实验室条件下稳定的化学计量还原剂硼氢化钠（NaBH4），在乙醇中于环境条件下进行反应。该反应已应用于末端烯烃的还原（22个实例，产率高达95%）和硝基的还原（26个实例，产率高达95%）。氘标记研究表明，该反应通过离子机制而非自由基机制进行。
