铁(III)/硼氢化钠介导的对非活化烯烃的加成：新型 20'-长春碱类似物的合成。
Iron(III)/NaBH4-mediated additions to unactivated alkenes: synthesis of novel 20'-vinblastine analogues.
机构信息
Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
出版信息
Org Lett. 2012 Mar 16;14(6):1428-31. doi: 10.1021/ol300173v. Epub 2012 Feb 28.
An Fe(III)/NaBH(4)-mediated reaction for the functionalization of unactivated alkenes is described defining the alkene substrate scope, establishing the exclusive Markovnikov addition, exploring a range of free radical traps, examining the Fe(III) salt and initiating hydride source, introducing H(2)O-cosolvent mixtures, and exploring catalytic variants. Its use led to the preparation of a novel, potent, and previously inaccessible C20'-vinblastine analogue.
描述了一种 Fe(III)/NaBH(4)介导的用于活化烯烃功能化的反应，确定了烯烃底物的范围，建立了烯烃的 Markovnikov 加成，探索了一系列自由基捕获剂，考察了 Fe(III)盐和引发氢化物源，引入了 H(2)O-共溶剂混合物，并探索了催化变体。该方法的应用导致了一种新型、有效且以前无法获得的 C20'-长春碱类似物的制备。
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