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双酚 A,一种能量平衡破坏剂。

BPA, an energy balance disruptor.

机构信息

a Laboratoire de Toxicologie Alimentaire, INSERM U866, NUTOX, Derttech Packtox , University of Burgundy , Dijon , France.

出版信息

Crit Rev Food Sci Nutr. 2015;55(6):769-77. doi: 10.1080/10408398.2012.678421.

Abstract

Bisphenol A (BPA) is used extensively in the world and is present in a diverse range of manufactured articles including dental resins, polycarbonate plastics, and the inner coating of food cans. It is a high volume chemical, with global production at 3.6 × 10(9) kg per year. BPA was identified as a high priority for assessment of human health risk because it was considered to present greatest potential for human exposure. Most studies of the health effects of BPA have focused on endocrine disruption leading to reproductive toxicity, but it displays additional side effects, including liver damage, disrupted pancreatic β-cell function, thyroid hormone disruption, and obesity-promoting effects. In this article, we reviewed specifically on the effects of BPA in energy balance.

摘要

双酚 A(BPA)在世界范围内广泛使用,存在于各种制成品中,包括牙科用树脂、聚碳酸酯塑料和食品罐的内涂层。它是一种高产量的化学物质,全球年生产量为 3.6×10^9 千克。BPA 被确定为需要优先评估其对人类健康风险的物质,因为它被认为对人类暴露的潜在风险最大。大多数关于 BPA 对健康影响的研究都集中在其内分泌干扰导致生殖毒性上,但它还表现出其他副作用,包括肝损伤、破坏胰腺β细胞功能、甲状腺激素紊乱和促进肥胖的作用。在本文中,我们专门综述了 BPA 对能量平衡的影响。

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