Kamaludin Roziana, Rasdi Zatilfarihiah, Othman Mohd Hafiz Dzarfan, Abdul Kadir Siti Hamimah Sheikh, Mohd Nor Noor Shafina, Khan Jesmine, Wan Mohamad Zain Wan Nor I'zzah, Ismail Ahmad Fauzi, A Rahman Mukhlis, Jaafar Juhana
Advanced Membrane Technology Research Centre (AMTEC), Universiti Teknologi Malaysia, Skudai 81310, Malaysia.
Institute of Medical Molecular Biotechnology, Faculty of Medicine, Sungai Buloh Campus, Universiti Teknologi MARA (UiTM), Jalan Hospital, Sungai Buloh 47000, Malaysia.
Membranes (Basel). 2020 Feb 21;10(2):32. doi: 10.3390/membranes10020032.
The presence of bisphenol A (BPA) in various water sources has potentially led to numerous adverse effects in human such as increased in blood pressure and derangement in liver function. Thus, a reliable treatment for the removing BPA is highly required. This present work aimed to study the efficiency of visible light driven photocatalytic dual-layer hollow fiber (DLHF) membrane for the removal of BPA from water and further investigated its detrimental effects by using an in-vivo model. The prepared membranes were characterized for their morphology, particles distribution, surface roughness, crystallinity and light absorption spectra. The removal of 81.6% and 86.7% in BPA concentration was achieved for N-doped TiO DLHF after 360 min of visible and UV light irradiation, respectively. No significant changes for all three groups were observed in liver function test meanwhile the rats-exposed to untreated BPA water shows significance blood pressure increment contrary to rats-exposed to treated BPA water. Similarly, the normal morphology in both jejunum and ileum were altered in rats-exposed to untreated BPA water group. Altogether, the presence of N-doped TiO in DLHF are shown to significantly enhance the photocatalytic degradation activity under visible irradiation, which effectively mitigates the effect of BPA in an in-vivo model.
各种水源中双酚A(BPA)的存在可能会给人类带来诸多不利影响,如血压升高和肝功能紊乱。因此,迫切需要一种可靠的去除双酚A的处理方法。本研究旨在探讨可见光驱动的光催化双层中空纤维(DLHF)膜从水中去除双酚A的效率,并通过体内模型进一步研究其有害影响。对制备的膜进行了形态、颗粒分布、表面粗糙度、结晶度和光吸收光谱等方面的表征。在可见光和紫外光照射360分钟后,N掺杂TiO₂ DLHF对双酚A浓度的去除率分别达到81.6%和86.7%。肝功能测试中,三组均未观察到显著变化,同时,饮用未处理双酚A水的大鼠血压显著升高,而饮用处理过双酚A水的大鼠则相反。同样,饮用未处理双酚A水的大鼠空肠和回肠的正常形态也发生了改变。总之,DLHF中N掺杂TiO₂ 的存在显著增强了可见光照射下的光催化降解活性,有效减轻了双酚A在体内模型中的影响。