骨桥蛋白在系统性红斑狼疮中的作用。
Role of osteopontin in systemic lupus erythematosus.
作者信息
Kaleta Beata
机构信息
Department of Clinical Immunology, Transplantation Institute, Medical University of Warsaw, Nowogrodzka 59, 02-006, Warsaw, Poland,
出版信息
Arch Immunol Ther Exp (Warsz). 2014 Dec;62(6):475-82. doi: 10.1007/s00005-014-0294-x. Epub 2014 Jun 11.
Abstract
Systemic lupus erythematosus (SLE) is a multisystemic disease, caused by a variety of factors, which lead to immunological abnormalities. Osteopontin (OPN) is a pleiotropic protein, important in bone remodeling and immune system signaling. OPN, produced by various cells, including immune cells, plays a key role in regulating T-helper 1/T-helper 2 balance, stimulating B lymphocytes to produce antibodies, regulating macrophages, neutrophils and inducing dendritic cells. OPN expression is influenced by genetic polymorphisms of its promoter, hormones and cytokines. Over expression of OPN has been associated with the pathogenesis of immune-mediated diseases. OPN has been implicated in the development of murine model of lupus and in humans with SLE. In this review, I will present current state of research on the role of OPN and OPN gene polymorphisms in pathogenesis and clinical course of SLE. A better understanding of the role of OPN in SLE will contribute to more precise diagnosis and treatment of the disease.
摘要
系统性红斑狼疮（SLE）是一种多系统疾病，由多种因素引起，这些因素会导致免疫异常。骨桥蛋白（OPN）是一种多效性蛋白质，在骨重塑和免疫系统信号传导中起重要作用。OPN由包括免疫细胞在内的各种细胞产生，在调节辅助性T细胞1/辅助性T细胞2平衡、刺激B淋巴细胞产生抗体、调节巨噬细胞、中性粒细胞以及诱导树突状细胞方面发挥关键作用。OPN的表达受其启动子的基因多态性、激素和细胞因子的影响。OPN的过度表达与免疫介导疾病的发病机制有关。OPN与狼疮小鼠模型的发展以及人类SLE有关。在这篇综述中，我将介绍关于OPN及其基因多态性在SLE发病机制和临床过程中的作用的当前研究状况。更好地理解OPN在SLE中的作用将有助于更精确地诊断和治疗该疾病。
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2
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