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Med Sci Monit. 2014 Aug 5;20:1376-82. doi: 10.12659/MSM.891247.

本文引用的文献

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Diagnostic and prognostic molecular biomarkers for prostate cancer.前列腺癌的诊断和预后分子标志物。
Histopathology. 2012 Jan;60(1):125-41. doi: 10.1111/j.1365-2559.2011.04083.x.
2
The optimal rebiopsy prostatic scheme depends on patient clinical characteristics: results of a recursive partitioning analysis based on a 24-core systematic scheme.最佳前列腺重复活检方案取决于患者的临床特征：基于 24 芯系统方案的递归分割分析结果。
Eur Urol. 2011 Oct;60(4):834-41. doi: 10.1016/j.eururo.2011.07.036. Epub 2011 Jul 30.
3
Is there a role for fatty acid synthase in the diagnosis of prostatic adenocarcinoma?: A comparison with AMACR.脂肪酸合酶在前列腺腺癌诊断中的作用？：与 AMACR 的比较。
Am J Clin Pathol. 2011 Aug;136(2):239-46. doi: 10.1309/AJCP0Y5QWWYDKCJE.
4
Comparison of the diagnostic value of fatty acid synthase (FASN) with alpha-methylacyl-CoA racemase (AMACR) as prostatic cancer tissue marker.脂肪酸合酶（FASN）与α-甲基酰基辅酶A消旋酶（AMACR）作为前列腺癌组织标志物的诊断价值比较。
Histopathology. 2010 May;56(6):811-5. doi: 10.1111/j.1365-2559.2010.03535.x.
5
A clinical dilemma; single prostatic cancer focus in biopsy. Interpretation and management.临床难题：活检中发现单一前列腺癌病灶。解读与处理
J BUON. 2010 Jan-Mar;15(1):19-24.
6
False-negative prostate needle biopsies: frequency, histopathologic features, and follow-up.前列腺针吸活检假阴性：频率、组织病理学特征和随访。
Am J Surg Pathol. 2010 Jan;34(1):35-43. doi: 10.1097/PAS.0b013e3181c3ece9.
7
The index lesion and the origin of prostate cancer.前列腺癌的索引病灶及起源
N Engl J Med. 2009 Oct 22;361(17):1704-6. doi: 10.1056/NEJMcibr0905562.
8
Cancer statistics, 2009.2009年癌症统计数据。
CA Cancer J Clin. 2009 Jul-Aug;59(4):225-49. doi: 10.3322/caac.20006. Epub 2009 May 27.
9
Copy number analysis indicates monoclonal origin of lethal metastatic prostate cancer.拷贝数分析表明致死性转移性前列腺癌起源于单克隆。
Nat Med. 2009 May;15(5):559-65. doi: 10.1038/nm.1944. Epub 2009 Apr 12.
10
Does transrectal ultrasound probe configuration really matter? End fire versus side fire probe prostate cancer detection rates.经直肠超声探头配置真的很重要吗？端射探头与侧射探头对前列腺癌的检测率
J Urol. 2009 May;181(5):2077-82; discussion 2082-3. doi: 10.1016/j.juro.2009.01.035. Epub 2009 Mar 14.

单灶性前列腺癌：当前的诊断与管理

Single foci prostate cancer: current diagnosis and management.

作者信息

Efthimiou Ioannis, Skrepetis Konstadinos, Bournia Elefteria

机构信息

Department of Urology, General Hospital of Kalamata, Kalamata, Greece.

Pathology, General Hospital of Kalamata, Kalamata, Greece.

出版信息

Curr Urol. 2013 Aug;7(1):1-6. doi: 10.1159/000343544. Epub 2013 Jul 28.

DOI:10.1159/000343544
PMID:24917748
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3783292/
Abstract

Diagnosis of small prostate cancer foci is a real challenge for pathologists and urologists as it carries the risk of false positive or negative diagnosis with clinical consequences. Diagnosis of small prostate cancer foci requires a strict methodological approach which includes a search for major and minor features under low and high magnification. Ambiguous cases can be further clarified with the use of basal cell immunomarkers complemented by a positive indicator of malignancy. Despite the new diagnostic armamentarium, a few cases will continue to remain doubtful and might require an appropriate rebiopsy.

摘要

诊断小前列腺癌病灶对病理学家和泌尿科医生来说是一项真正的挑战，因为这存在假阳性或假阴性诊断的风险，并会产生临床后果。诊断小前列腺癌病灶需要一种严格的方法，包括在低倍和高倍放大下寻找主要和次要特征。对于不明确的病例，可以使用基底细胞免疫标记物并辅以恶性肿瘤阳性指标来进一步明确。尽管有新的诊断手段，但仍有一些病例会继续存在疑问，可能需要进行适当的再次活检。