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脑膜炎奈瑟菌中,颊细胞黏附失败及表面疏水性作为毒力标志物的研究

Failure of adherence to buccal cells and surface hydrophobicity as virulence markers in Neisseria meningitidis.

作者信息

Criado M T, Sáinz V, del Río M C, Ferreirós C M, Criado J, Carballo J, Souto M J

机构信息

Departamento de Microbiología y Parasitología, Facultad de Farmacia, Universidad de Santiago, Santiago de Compostela, Spain.

出版信息

Med Microbiol Immunol. 1989;178(1):53-9. doi: 10.1007/BF00202292.

DOI:10.1007/BF00202292
PMID:2491905
Abstract

Surface hydrophobicity and adherence to buccal epithelial cells were studied in 33 carrier and 34 invasive Neisseria meningitidis strains. It was found that hydrophobicity is statistically similar in both groups (P = 0.0507) although it could be considered that carrier strains are slightly more hydrophobic than invasive ones. Adherence was similar in both groups although more homogeneous in the carrier strains. No correlation could be demonstrated between these two properties nor can they be considered relevant as markers of the carrier or invasive status of this bacterium, indicating that at least in N. meningitidis they are not good properties to discriminate virulent strains.

摘要

对33株携带型和34株侵袭型脑膜炎奈瑟菌菌株的表面疏水性及对颊上皮细胞的黏附性进行了研究。结果发现,两组菌株的疏水性在统计学上相似(P = 0.0507),不过可以认为携带型菌株的疏水性略高于侵袭型菌株。两组的黏附性相似,不过携带型菌株的黏附性更均匀。这两种特性之间未显示出相关性,也不能将它们视为该细菌携带状态或侵袭状态的相关标志物,这表明至少对于脑膜炎奈瑟菌而言,它们并非区分毒力菌株的良好特性。

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本文引用的文献

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Nutritional profiles of Neisseria gonorrhoeae, Neisseria meningitidis, and Neisseria lactamica in chemically defined media and the use of growth requirements for gonococcal typing.淋病奈瑟菌、脑膜炎奈瑟菌和乳糖奈瑟菌在化学成分明确的培养基中的营养特征以及淋病奈瑟菌分型生长需求的应用。
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Adherence and hydrophobicity in Neisseria meningitidis and their relationship with surface charge.
Med Microbiol Immunol. 1985;174(3):151-6. doi: 10.1007/BF02298125.
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Evaluation of hydrophobicity and adherence of Neisseria meningitidis strains and a study of their correlation by analysis of alterations induced by antibiotics.脑膜炎奈瑟菌菌株的疏水性和黏附性评估及其与抗生素诱导变化相关性的分析研究
Ann Inst Pasteur Microbiol (1985). 1986 Jul-Aug;137B(1):37-45. doi: 10.1016/s0769-2609(86)80092-8.
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Characterization of Neisseria polysacchareae sp. nov. (Riou, 1983) in previously identified noncapsular strains of Neisseria meningitidis.脑膜炎奈瑟菌先前鉴定的无荚膜菌株中多糖奈瑟菌新种(Riou,1983)的特征描述。
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Studies on the implication of surface hydrophobicity in the adherence of Neisseria meningitidis to buccal epithelial cells.关于表面疏水性在脑膜炎奈瑟菌黏附颊上皮细胞中的作用的研究。
Med Microbiol Immunol. 1986;175(1):27-34. doi: 10.1007/BF02123126.
10
Role of R-plasmids in adherence and hydrophobicity in Escherichia coli.R质粒在大肠杆菌黏附及疏水性中的作用
J Hosp Infect. 1987 Mar;9(2):175-81. doi: 10.1016/0195-6701(87)90057-0.