Chen Lihua, Zhang Jiuquan, Chen Yongfeng, Wang Wenwei, Zhou Xiangdong, Yan Xiaochu, Wang Jian
Department of Radiology, Southwest Hospital, Third Military Medical University, Chongqing, China; Department of Radiology, PLA 101st Hospital, Wuxi Jiangsu, China.
Department of Radiology, Southwest Hospital, Third Military Medical University, Chongqing, China.
PLoS One. 2014 Jun 11;9(6):e99865. doi: 10.1371/journal.pone.0099865. eCollection 2014.
To prospectively investigate the relationship between the apparent diffusion coefficient (ADC) and cellularity in lung cancer.
Sixty patients histopathologically confirmed with lung cancer (41 men, 19 women) underwent diffusion-weighted magnetic resonance imaging of the chest (with b values of 50 and 1000 s/mm2). The median mean ADC (ADC mean) value and median minimum ADC (ADC min) value within each primary tumour were calculated and compared with the median nucleo-cytoplasmic ratio (NCR), which was selected to represent the cellularity. The correlation between the NCR and ADC mean/ADC min was calculated with SPSS 18.0 software.
The mean ADC mean values, ADC min values and median NCR were (1.07 ± 0.12) × 10(-3) mm2/s, (0.86 ± 0.14) × 10(-3) mm2/s, and (14.9 ± 2.6) %, respectively, in adenocarcinoma; (0.88 ± 0.10) × 10(-3) mm2/s, (0.73 ± 0.12) × 10(-3)) mm2/s, and (20.6 ± 4.4) %, respectively, in squamous cell carcinoma; and (0.89 ± 0.13) × 10(-3) mm2/s, (0.67 ± 0.13) × 10(-3) mm2/s, and (18.3 ± 3.5) %, respectively in small cell lung cancer. The NCR of squamous cell carcinoma and small cell lung cancer is greater than that of adenocarcinoma (P < 0.01 and P = 0.002, respectively). There was an inverse relationship between ADC mean/NCR and ADC min/NCR (r = -0.60, P = 0.001 and r = -0.47, P < 0.001, respectively).
There is a significant inverse relationship between tumour cellularity and ADC in lung cancer. However, tumour cellularity most likely is not the sole determinant of the ADC.
前瞻性研究肺癌中表观扩散系数（ADC）与细胞密度之间的关系。
60例经组织病理学确诊为肺癌的患者（男性41例，女性19例）接受了胸部扩散加权磁共振成像检查（b值为50和1000 s/mm²）。计算每个原发性肿瘤内的中位平均ADC（ADC mean）值和中位最小ADC（ADC min）值，并与选择用来代表细胞密度的中位核质比（NCR）进行比较。使用SPSS 18.0软件计算NCR与ADC mean/ADC min之间的相关性。
腺癌的平均ADC mean值、ADC min值和中位NCR分别为(1.07 ± 0.12) × 10⁻³ mm²/s、(0.86 ± 0.14) × 10⁻³ mm²/s和(14.9 ± 2.6) %；鳞状细胞癌分别为(0.88 ± 0.10) × 10⁻³ mm²/s、(0.73 ± 0.12) × 10⁻³ mm²/s和(20.6 ± 4.4) %；小细胞肺癌分别为(0.89 ± 0.13) × 10⁻³ mm²/s、(0.67 ± 0.13) × 10⁻³ mm²/s和(18.3 ± 3.5) %。鳞状细胞癌和小细胞肺癌的NCR大于腺癌（分别为P < 0.01和P = 0.002）。ADC mean/NCR与ADC min/NCR之间存在负相关（分别为r = -0.60，P = 0.001和r = -0.47，P < 0.001）。
肺癌中肿瘤细胞密度与ADC之间存在显著的负相关。然而，肿瘤细胞密度很可能不是ADC的唯一决定因素。
