补充火龙果果汁对高碳水化合物、高脂肪饮食诱导的代谢综合征大鼠心血管和肝脏变化的影响。
Effects of red pitaya juice supplementation on cardiovascular and hepatic changes in high-carbohydrate, high-fat diet-induced metabolic syndrome rats.
作者信息
Ramli Nurul Shazini, Brown Lindsay, Ismail Patimah, Rahmat Asmah
机构信息
Department of Nutrition and Dietetics, Universiti Putra Malaysia, Serdang 43400 UPM, Malaysia.
出版信息
BMC Complement Altern Med. 2014 Jun 12;14:189. doi: 10.1186/1472-6882-14-189.
BACKGROUND
The fruit of Hylocereus polyrhizus, also known as red pitaya, and buah naga in Malay, is one of the tropical fruits of the cactus family, Cactaceae. Red pitaya has been shown to protect aorta from oxidative damage and improve lipid profiles in hypercholesterolemic rats probably due to phytochemicals content including phenolics and flavonoids. The aim of this study was to investigate the changes in cardiac stiffness, hepatic and renal function in high-carbohydrate, high-fat diet-induced obese rats following supplementation of red pitaya juice.
METHODS
Total 48 male Wistar rats were divided into 4 groups: corn-starch group (CS), corn-starch+red pitaya juice group (CRP), high-carbohydrate, high fat group (HCHF) and high-carbohydrate, high fat+red pitaya juice (HRP). The intervention with 5% red pitaya juice was started for 8 weeks after 8 weeks initiation of the diet. Heart function was determined ex vivo with Langendorff hearts while plasma liver enzymes, uric acid and urea were measured using commercial kits. Total fat mass was determined with Dual-energy X-ray absorptiometry (DXA) scan. Glucose uptake was measured with Oral Glucose Tolerance Test (OGTT). Liver and cardiac structures were defined by histology.
RESULTS
Supplementation of red pitaya juice for 8 weeks increased energy intake and abdominal circumference but no change in body fat and lean mass respectively. Also, there were a trend of uric acid and glucose normalization for HRP as compared to H-fed rats. Red pitaya juice treatment reduced ALP and ALT but caused significant increment in AST. Diastolic stiffness of the heart was reduced after supplementation of red pitaya juice in corn starch fed rats. However, the reduction was not significant in HRP rats in comparison with H rats.
CONCLUSION
The present study concluded that red pitaya juice may serve as a complimentary therapy for attenuating some signs of metabolic syndrome.
背景
量天尺果实，也被称为红火龙果，在马来语中称为buah naga，是仙人掌科的热带水果之一。红火龙果已被证明可以保护主动脉免受氧化损伤，并改善高胆固醇血症大鼠的血脂状况，这可能归因于其含有的酚类和黄酮类等植物化学物质。本研究的目的是调查在高碳水化合物、高脂肪饮食诱导的肥胖大鼠中补充红火龙果汁后心脏僵硬度、肝肾功能的变化。
方法
总共48只雄性Wistar大鼠被分为4组：玉米淀粉组（CS）、玉米淀粉+红火龙果汁组（CRP）、高碳水化合物、高脂肪组（HCHF）和高碳水化合物、高脂肪+红火龙果汁组（HRP）。在开始饮食8周后，开始用5%的红火龙果汁进行干预，持续8周。离体使用Langendorff心脏测定心脏功能，同时使用商用试剂盒测量血浆肝酶、尿酸和尿素。用双能X线吸收法（DXA）扫描测定总脂肪量。用口服葡萄糖耐量试验（OGTT）测量葡萄糖摄取。通过组织学确定肝脏和心脏结构。
结果
补充红火龙果汁8周增加了能量摄入和腹围，但身体脂肪和瘦体重分别没有变化。此外，与高脂喂养的大鼠相比，HRP组有尿酸和血糖正常化的趋势。红火龙果汁处理降低了碱性磷酸酶（ALP）和谷丙转氨酶（ALT），但导致谷草转氨酶（AST）显著升高。在玉米淀粉喂养的大鼠中补充红火龙果汁后，心脏舒张僵硬度降低。然而，与高脂组大鼠相比，HRP组大鼠的降低不显著。
结论
本研究得出结论，红火龙果汁可能作为一种辅助疗法来减轻代谢综合征的一些症状。
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