Choi Edmond P H, Lam Cindy L K, Chin Weng-Yee
Department of Family Medicine and Primary Care, The University of Hong Kong, 3/F., 161 Main Street, Ap Lei Chau Clinic, Ap Lei Chau, Hong Kong,
Qual Life Res. 2014 Dec;23(10):2723-33. doi: 10.1007/s11136-014-0725-5. Epub 2014 Jun 12.
The aim of this study was to evaluate the health-related quality of life (HRQOL) of Chinese primary care patients with lower urinary tract symptoms (LUTS).
Five hundred and nineteen primary care subjects with LUTS completed a structured questionnaire containing the International Prostate Symptom Score, the adapted Incontinence Impact Questionnaire-7, the International Consultation on Incontinence Questionnaire-Urinary Incontinence Short Form, the Chinese (HK) SF-12 Health Survey Version 2 (SF-12 v2) and the Depression, Anxiety and Stress Scale-21.
LUTS patients had poorer HRQOL for the General Health and the Vitality domains and lower Physical Component Summary scores, but better HRQOL for the Role Emotion domain than the adjusted Hong Kong population norms. Clinical factors associated with poorer HRQOL measured by the SF-12 v2 included having more severe LUTS and having more severe depressive, anxiety and stress symptoms. Socio-demographic factors associated with poorer SF-12 v2 were consistent with those found in the general populations. Clinical and socio-demographic factors associated with poorer HRQOL assessed by condition-specific measures included having more severe LUTS (excluding intermittency and straining), the presence of mixed urinary incontinence, having more severe anxiety and stress symptoms, younger age, being not married, being in employment and having a lower household income.
LUTS had substantial negative impact on patients' overall health perception and global well-being in Chinese population. A decline in HRQOL might be a key determinant for Chinese patients with LUTS to seek treatment. Patients with nocturia, frequency, urgency or mixed urinary incontinence and younger patients deserve more treatment attention because they appear to have poorer HRQOL.
本研究旨在评估中国基层医疗中患有下尿路症状（LUTS）患者的健康相关生活质量（HRQOL）。
519名患有LUTS的基层医疗受试者完成了一份结构化问卷，其中包括国际前列腺症状评分、改编后的尿失禁影响问卷 - 7、国际尿失禁咨询问卷 - 尿失禁简表、中国（香港）SF - 12健康调查第2版（SF - 12 v2）以及抑郁、焦虑和压力量表 - 21。
与调整后的香港人群规范相比，LUTS患者在总体健康和活力领域的HRQOL较差，身体成分总结得分较低，但在角色情感领域的HRQOL较好。SF - 12 v2测量的与较差HRQOL相关的临床因素包括LUTS更严重以及抑郁、焦虑和压力症状更严重。与较差的SF - 12 v2相关的社会人口统计学因素与一般人群中发现的因素一致。通过特定疾病测量评估的与较差HRQOL相关的临床和社会人口统计学因素包括LUTS更严重（不包括间歇性和用力情况）、存在混合性尿失禁、焦虑和压力症状更严重、年龄较小、未婚、就业以及家庭收入较低。
LUTS对中国人群患者的整体健康认知和总体幸福感有重大负面影响。HRQOL下降可能是中国LUTS患者寻求治疗的关键决定因素。夜尿症、尿频、尿急或混合性尿失禁患者以及年轻患者应得到更多治疗关注，因为他们的HRQOL似乎较差。
