Okada Takuya, Kono Yuka, Matsumoto Keiyu, Sumiyoshi Takayuki, Masuda Norihiko, Shiraishi Yusuke, Negoro Hiromitsu, Utsunomiya Noriaki, Tsunemori Hiroyuki, Okubo Kazutoshi, Segawa Takehiko, Moroi Seiji, Muguruma Koei, Kawakita Mutsushi
Nihon Hinyokika Gakkai Zasshi. 2015 Jul;106(3):172-7. doi: 10.5980/jpnjurol.106.172.
We investigated the impact of lower urinary tract symptoms (LUTS) on generic health-related quality of life (HRQOL) in male patients without co-morbidity.
From 2003 to 2011, a total 567 men who presented out urological department completed the questionnaires including International Prostate Symptom Score (IPSS), incontinence-frequency score (IFS) from the UCLA prostate cancer index, MOS 36-Item Short-Form Health Survey (SF-36). Among 230 patients with no coexisting morbidity, the relations between each LUTS score of IPSS indices and IFS and 8 domain scores of SF-36 were analyzed by Pearson's product-moment correlation and stepwise multiple regression analysis.
Univariate analysis showed that the IFS had a significant correlation with all of 8 domain scores of SF-36, and also the IPSS item scores of urgency, nocturia and straining correlated significantly with multiple domain scores of SF-36. In multiple regression analysis, the proportionate contributions of LUTS to each SF-36 domain scores were low (R2 was 10% or less). Incontinence was considered as the most influential factor that had a negative impact on HRQOL in 7 SF-36 domains of physical functioning, role-physical, bodily pain, general health perception, vitality, social functioning and mental health. Additionally, nocturia, straining and urgency were significantly associated with deficit of HRQOL in 4 SF-36 domains (role-physical, general health perception, role-emotional, mental health), 2 domains (bodily pain, social functioning) and 1 domain (role-emotional) of SF-36, respectively. CONCLUSION; Among LUTS, incontinence, nocturia and straining were the most important symptoms in association with the negative impact on generic HRQOL measured by SF-36.
我们研究了下尿路症状（LUTS）对无合并症男性患者一般健康相关生活质量（HRQOL）的影响。
2003年至2011年，共有567名到泌尿外科就诊的男性完成了问卷调查，包括国际前列腺症状评分（IPSS）、加州大学洛杉矶分校前列腺癌指数中的尿失禁频率评分（IFS）、医学结局研究36项简明健康调查（SF-36）。在230例无合并症的患者中，通过Pearson积差相关分析和逐步多元回归分析，分析了IPSS指数和IFS的各LUTS评分与SF-36的8个领域评分之间的关系。
单因素分析显示，IFS与SF-36的所有8个领域评分均有显著相关性，IPSS中的尿急、夜尿和用力排尿项目评分也与SF-36的多个领域评分显著相关。在多元回归分析中，LUTS对每个SF-36领域评分的贡献比例较低（R²为10%或更低）。尿失禁被认为是对SF-36的身体功能、角色-身体、身体疼痛、总体健康感知、活力、社会功能和心理健康等7个领域的HRQOL产生负面影响的最具影响力的因素。此外，夜尿、用力排尿和尿急分别与SF-36的4个领域（角色-身体、总体健康感知、角色-情感、心理健康）、2个领域（身体疼痛、社会功能）和1个领域（角色-情感）的HRQOL缺陷显著相关。结论：在LUTS中，尿失禁、夜尿和用力排尿是与SF-36测量的一般HRQOL负面影响相关的最重要症状。
