L-二羟基苯丙氨酸可诱导毛孢子菌属成员产生黑色素。
L-Dihydroxyphenylalanine induces melanin production by members of the genus Trichosporon.
作者信息
Figueiredo-Carvalho Maria Helena Galdino, dos Santos Fábio B, Nosanchuk Joshua D, Zancope-Oliveira Rosely M, Almeida-Paes Rodrigo
机构信息
Laboratório de Micologia, Instituto de Pesquisa Clínica Evandro Chagas, Fundação Oswaldo Cruz, Manguinhos, Rio de Janeiro, Brazil.
出版信息
FEMS Yeast Res. 2014 Sep;14(6):988-91. doi: 10.1111/1567-1364.12174. Epub 2014 Jun 30.
Abstract
Melanization of members of the genus Trichosporon is poorly described. In this study, six strains, including two clinical isolates, from four different species (Trichosporon asahii, T. asteroides, T. inkin, and T. mucoides) were grown in culture media with or without L-dihydroxyphenylalanine (L-DOPA). Each strain produced a brownish pigment compatible with melanin when cultured in presence of L-DOPA, suggesting that these species are able to produce eumelanin. L-tyrosine was not able to elicit any type of pigment production on cultures. As eumelanin is produced by several fungi during parasitism, this pigment may contribute to Trichosporon virulence.
摘要
丝孢酵母属成员的黑化现象鲜有描述。在本研究中，从四个不同物种（阿萨希丝孢酵母、星状丝孢酵母、因金丝孢酵母和黏液丝孢酵母）中选取了六个菌株，包括两个临床分离株，分别在添加或不添加L - 二羟基苯丙氨酸（L - DOPA）的培养基中培养。当在L - DOPA存在的情况下培养时，每个菌株都会产生一种与黑色素相符的褐色色素，这表明这些物种能够产生真黑素。L - 酪氨酸在培养物中无法引发任何类型的色素产生。由于几种真菌在寄生过程中会产生真黑素，这种色素可能有助于丝孢酵母的毒力。
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