Peña Cristina, Suarez Lourdes, Bautista-Castaño Inmaculada, Juste M Candelaria, Carretón Elena, Montoya-Alonso José Alberto
Veterinary Medicine Service, Faculty of Veterinary Medicine, University of Las Palmas de Gran Canaria, Las Palmas, Spain.
J Vet Med Sci. 2014 Sep;76(9):1305-8. doi: 10.1292/jvms.13-0475. Epub 2014 Jun 11.
The aim of the present study was to compare the impact on blood pressure and different metabolic parameters of a weight-loss program on obese dogs fed on a low-fat high-fibre diet and treated with and without mitratapide. The study sample consisted of 36 obese dogs, randomly assigned to a control group (n=17), which were fed on a low-fat high-fibre diet, and an intervention group (n=19), fed on the same diet and treated with mitratapide. Variables measured included body condition score, body weight, heart rate, systolic and diastolic blood pressures; total cholesterol, triglycerides and glucose levels; alanine aminotransferase and alkaline phosphatase activity, measured both at baseline (day 0) and at the end of the weight loss program (day 85). All the studied parameters had decreased in both groups at the end of the study; these being diastolic blood pressure, total cholesterol and alanine aminotransferase, significantly lower in dogs treated with mitratapide. The use of mitrapide in addition to low-fat high-fibre diet does not seem to offer any further useful effect in the loss of weight during the treatment of canine obesity. On the other hand, mitratapide seems to present certain beneficial effects on pathologies associated with obesity, these being mainly related to blood pressure, lipids and hepatic parameters.
本研究的目的是比较低脂高纤维饮食且分别接受米曲美肽治疗和未接受米曲美肽治疗的减肥方案对肥胖犬血压和不同代谢参数的影响。研究样本包括36只肥胖犬，随机分为对照组（n = 17），喂食低脂高纤维饮食；干预组（n = 19），喂食相同饮食并接受米曲美肽治疗。测量的变量包括身体状况评分、体重、心率、收缩压和舒张压；总胆固醇、甘油三酯和葡萄糖水平；丙氨酸转氨酶和碱性磷酸酶活性，在基线（第0天）和减肥方案结束时（第85天）进行测量。在研究结束时，两组中所有研究参数均有所下降；其中舒张压、总胆固醇和丙氨酸转氨酶，在接受米曲美肽治疗的犬中显著降低。在犬类肥胖治疗期间，除低脂高纤维饮食外使用米曲美肽似乎对体重减轻没有进一步的有益作用。另一方面，米曲美肽似乎对与肥胖相关的病症具有某些有益作用，这些作用主要与血压、血脂和肝脏参数有关。
