科威特一家三级护理医院及其周边地区嗜热曲霉分离株的空气传播流行情况及其致病性评估。
Aerial prevalence of Aspergillus calidoustus isolates in and around a tertiary care hospital in Kuwait and assessment of their pathogenicity.
作者信息
Khan Ziauddin, Ahmad Suhail, Joseph Leena
机构信息
Department of Microbiology, Faculty of Medicine, Kuwait University, Safat, Kuwait
Department of Microbiology, Faculty of Medicine, Kuwait University, Safat, Kuwait.
出版信息
J Clin Microbiol. 2014 Sep;52(9):3402-5. doi: 10.1128/JCM.01181-14. Epub 2014 Jun 11.
Abstract
Seven Aspergillus calidoustus isolates from 486 Aspergillus spp. isolates (1.4% overall prevalence) from outdoor/indoor air samples and one isolate from the bronchoalveolar lavage fluid of a patient with pneumonia were obtained. These 8 isolates exhibited reduced susceptibility to triazoles. Preliminary pathogenicity data from BALB/c mice suggest that A. calidoustus can persist in tissues for long periods without causing mortality. Further studies using graded doses of inoculum and immunosuppression models are warranted to gain an understanding of the factors associated with its pathogenicity and virulence.
摘要
从486株曲霉属菌株（室外/室内空气样本中分离得到，总体患病率为1.4%）中获得了7株热栖曲霉分离株，以及从一名肺炎患者的支气管肺泡灌洗 fluid中获得了1株分离株。这8株分离株对三唑类药物的敏感性降低。来自BALB/c小鼠的初步致病性数据表明，热栖曲霉可在组织中长期存活而不导致死亡。有必要进一步使用分级剂量接种物和免疫抑制模型进行研究，以了解与其致病性和毒力相关的因素。
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