膳食蛋白质摄入量与中风风险的定量分析。
Quantitative analysis of dietary protein intake and stroke risk.
作者信息
Zhang Zhizhong, Xu Gelin, Yang Fang, Zhu Wusheng, Liu Xinfeng
机构信息
From the Department of Neurology, Jinling Hospital, Nanjing University School of Medicine, Jiangsu Province, China.
出版信息
Neurology. 2014 Jul 1;83(1):19-25. doi: 10.1212/WNL.0000000000000551. Epub 2014 Jun 11.
OBJECTIVE
To perform a meta-analysis of prospective studies to evaluate the relation between dietary protein intake and stroke risk.
METHODS
Relevant studies were identified by searching PubMed and Embase through November 2013, and by reviewing the reference lists of retrieved articles. We included prospective cohort studies that reported relative risks (RRs) with 95% confidence intervals (CIs) for the association between dietary protein intake and stroke risk.
RESULTS
The meta-analysis included 7 prospective studies involving 254,489 participants. The pooled RR of stroke for the highest compared with the lowest dietary protein intake was 0.80 (95% CI 0.66-0.99). Dose-response analysis indicated that a 20-g/d increment in dietary protein intake was associated with a 26% reduction in stroke risk. Stratifying by protein type, the RR of stroke for animal protein was 0.71 (95% CI 0.50-0.99). Sensitivity analysis restricted to studies with control for common risk factors yielded similar results, and omission of any single study did not change the overall result.
CONCLUSION
These findings suggest that moderate dietary protein intake may lower the risk of stroke.
目的
进行前瞻性研究的荟萃分析，以评估膳食蛋白质摄入量与中风风险之间的关系。
方法
通过检索截至2013年11月的PubMed和Embase，并查阅检索文章的参考文献列表来确定相关研究。我们纳入了前瞻性队列研究，这些研究报告了膳食蛋白质摄入量与中风风险之间关联的相对风险（RRs）及95%置信区间（CIs）。
结果
荟萃分析纳入了7项前瞻性研究，涉及254,489名参与者。与最低膳食蛋白质摄入量相比，最高摄入量时中风的合并RR为0.80（95%CI 0.66 - 0.99）。剂量反应分析表明，膳食蛋白质摄入量每增加20克/天，中风风险降低26%。按蛋白质类型分层，动物蛋白摄入时中风的RR为0.71（95%CI 0.50 - 0.99）。仅限于对常见风险因素进行控制的研究的敏感性分析得出了类似结果，剔除任何一项研究都未改变总体结果。
结论
这些发现表明，适度的膳食蛋白质摄入可能会降低中风风险。
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