蛋白质摄入与心血管疾病：德国营养学会蛋白质摄入循证指南系统评价的综合评价

Protein intake and cardiovascular diseases: an umbrella review of systematic reviews for the evidence-based guideline on protein intake of the German Nutrition Society.

作者信息

Egert Sarah, Amini Anna M, Klug Lea, Kalotai Nicole, Haardt Julia, Boeing Heiner, Buyken Anette E, Kroke Anja, Lorkowski Stefan, Louis Sandrine, Nimptsch Katharina, Schulze Matthias B, Schwingshackl Lukas, Siener Roswitha, Stangl Gabriele I, Zittermann Armin, Watzl Bernhard, Ellinger Sabine

机构信息

Institute of Nutritional and Food Science, Nutritional Physiology, University of Bonn, Bonn, Germany.

German Nutrition Society, Bonn, Germany.

出版信息

Eur J Nutr. 2025 Aug 13;64(6):254. doi: 10.1007/s00394-025-03746-2.

DOI:10.1007/s00394-025-03746-2

PMID:40802072

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12350521/

Abstract

PURPOSE

This umbrella review aimed to investigate the evidence for an association of dietary intake of total protein as well as animal and plant protein with the incidence of coronary heart disease (CHD), stroke and total cardiovascular diseases (CVD).

METHODS

PubMed, Embase and Cochrane Database were systematically searched for systematic reviews (SRs) of prospective studies with or without meta-analysis (MA) published between January 2012 and April 2024. Methodological quality, outcome-specific certainty of evidence, and overall certainty of evidence were assessed using established tools and predefined criteria.

RESULTS

Ten SRs were considered eligible for the umbrella review; all were based on prospective cohort studies, and six conducted a MA. Dietary intakes of total, animal and plant protein were not associated with the risk of CHD or stroke. For CHD, the overall certainty of evidence for the absence of an association was "probable" for total, animal and plant protein. For stroke and total CVD, the overall certainty of evidence was rated as "possible" for the absence of an association with the intake of total protein and plant protein and insufficient for animal protein intake.

CONCLUSION

Given that most SRs on dietary protein intake did not indicate an association, it seems that protein intake plays no major role in the development of CVD. This investigation was registered at PROSPERO as CRD42018082395.

摘要

目的

本伞形综述旨在研究膳食中总蛋白质以及动物蛋白和植物蛋白的摄入量与冠心病（CHD）、中风及总心血管疾病（CVD）发病率之间关联的证据。

方法

系统检索了PubMed、Embase和Cochrane数据库，以查找2012年1月至2024年4月发表的有或无荟萃分析（MA）的前瞻性研究的系统评价（SRs）。使用既定工具和预定义标准评估方法学质量、特定结局的证据确定性以及总体证据确定性。

结果

十篇系统评价被认为符合伞形综述的条件；所有均基于前瞻性队列研究，其中六篇进行了荟萃分析。膳食中总蛋白质、动物蛋白和植物蛋白的摄入量与冠心病或中风风险无关。对于冠心病，总蛋白质、动物蛋白和植物蛋白缺乏关联的总体证据确定性为“可能”。对于中风和总心血管疾病，总蛋白质和植物蛋白摄入量缺乏关联的总体证据确定性被评为“可能”，而动物蛋白摄入量的证据不足。