类黄酮醇摄入量与中风风险：队列研究的荟萃分析。

Flavonol intake and stroke risk: a meta-analysis of cohort studies.

机构信息

Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Central Laboratory, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.

出版信息

Nutrition. 2014 May;30(5):518-23. doi: 10.1016/j.nut.2013.10.009. Epub 2013 Oct 19.

DOI:10.1016/j.nut.2013.10.009

PMID:24342529

Abstract

OBJECTIVE

Epidemiologic findings are inconsistent regarding the association between flavonol intake and the risk for stroke. The aim of this study was to determine whether an association exists between them in observational studies.

METHODS

We searched the PubMed and EMBASE databases for studies conducted from 1966 to August 2013. Prospective cohort studies that provided relative risk (RR) estimates with 95% confidence intervals (CIs) for the association between flavonol intake and risk for stroke were included. A random effects model was used to combine study-specific risk estimates.

RESULTS

The meta-analysis included eight studies, with 5228 stroke cases among 280 174 participants. The summary RR indicated a significant association between highest flavonol intake and reduced risk for stroke (summary RR, 0.86; 95% CI, 0.75-0.99). Furthermore, an increase in flavonol intake of 20 mg/d was associated with a 14% decrease in the risk for developing stroke (summary RR, 0.86; 95% CI, 0.77-0.96). Subgroup analyses suggested a significant inverse association between highest flavonol intake and stroke risk among men (summary RR, 0.74; 95% CI, 0.56-0.97) but not women (summary RR, 0.99; 95% CI, 0.85-1.16).

CONCLUSIONS

Higher dietary flavonol intake is associated with a reduced risk for stroke, especially among men. Our results support recommendations for higher consumption of flavonol-rich foods to prevent stroke.

摘要

目的

关于黄酮醇摄入量与中风风险之间的关联，流行病学研究结果并不一致。本研究旨在确定观察性研究中是否存在这种关联。

方法

我们检索了 1966 年至 2013 年 8 月期间发表的 PubMed 和 EMBASE 数据库中的研究。纳入了提供黄酮醇摄入量与中风风险之间关联的相对风险（RR）估计值和 95%置信区间（CI）的前瞻性队列研究。采用随机效应模型对研究特异性风险估计值进行合并。

结果

meta 分析纳入了 8 项研究，共有 280174 名参与者中有 5228 例中风病例。汇总 RR 表明，黄酮醇摄入量最高与中风风险降低之间存在显著关联（汇总 RR，0.86；95%CI，0.75-0.99）。此外，黄酮醇摄入量增加 20mg/d 与中风风险降低 14%相关（汇总 RR，0.86；95%CI，0.77-0.96）。亚组分析表明，黄酮醇摄入量最高与男性中风风险之间存在显著负相关（汇总 RR，0.74；95%CI，0.56-0.97），但在女性中无此相关性（汇总 RR，0.99；95%CI，0.85-1.16）。