Ottman R
Gertrude H. Sergievsky Center, Columbia University, New York, New York 10032.
Epilepsia. 1989 Jan-Feb;30(1):107-11. doi: 10.1111/j.1528-1157.1989.tb05290.x.
The research literature is consistent in reporting somewhat less familial aggregation in partial than in generalized epilepsy. However, relatives of patients with partial seizures do appear to have higher seizure risks than relatives of controls, suggesting that genetic factors are important in at least some partial epilepsies. Complex partial epilepsy appears to be only slightly less familial than other types of epilepsy. Relatives of patients with focal EEG abnormalities generally have been found to have lower risk of both EEG abnormalities and epilepsy than relatives of patients with generalized abnormalities. For focal temporocentral abnormalities, however, there is evidence of an important influence of genetic factors.
研究文献一致报道，部分性癫痫的家族聚集性略低于全身性癫痫。然而，部分性发作患者的亲属癫痫发作风险似乎确实高于对照组亲属，这表明遗传因素在至少某些部分性癫痫中很重要。复杂部分性癫痫的家族聚集性似乎仅略低于其他类型的癫痫。一般发现，局灶性脑电图异常患者的亲属出现脑电图异常和癫痫的风险低于全身性异常患者的亲属。然而，对于颞中央局灶性异常，有证据表明遗传因素有重要影响。
