Forman R G, Eychenne B, Nessmann C, Frydman R, Robel P
Sce de Gynécologie-Obstetrique, Hôpital Antoine Béclère, Clamart, France.
Fertil Steril. 1989 Feb;51(2):310-6. doi: 10.1016/s0015-0282(16)60496-x.
The corpus luteum-endometrial unit was investigated in in vitro fertilization (IVF) cycles using endocrine, morphologic, and biochemical measurements on the day normally scheduled for embryo transfer (day 16), in 12 stimulated and 4 natural cycles. Advanced endometrial histologic maturity was recorded in 9 of the 12 stimulated cycles. No in-phase endometria were seen when the preovulatory plasma estradiol (E2) was greater than 500 pg/ml or the day 16 plasma progesterone (P) greater than 10 ng/ml in natural or stimulated cycles. Significant negative correlations were noted between both preovulatory E2 and day 16 P and the concentration of cytosolic progesterone receptor (PRc). Advanced endometrial maturity tended to be associated with low concentrations of PRc. Regardless of endometrial maturity, the natural cycle was characterized by low cytosolic E2 receptors (ERc) and high PRc, whereas the concentration of both receptors was usually greatly reduced in stimulated cycles. It is concluded that the advanced endometrial maturation observed in stimulated IVF cycles is a consequence of the production of supraphysiologic levels of sex steroids by the corpus luteum that cause profound modifications of endometrial receptor dynamics.
在12个促排卵周期和4个自然周期中，于正常计划进行胚胎移植的日子（第16天），通过内分泌、形态学和生物化学测量，对黄体 - 子宫内膜单位进行了研究。在12个促排卵周期中的9个记录到子宫内膜组织学成熟度提前。在自然周期或促排卵周期中，当排卵前血浆雌二醇（E2）大于500 pg/ml或第16天血浆孕酮（P）大于10 ng/ml时，未观察到同步子宫内膜。排卵前E2和第16天P与胞质孕酮受体（PRc）浓度之间均存在显著负相关。子宫内膜成熟度提前往往与PRc低浓度相关。无论子宫内膜成熟度如何，自然周期的特征是胞质雌二醇受体（ERc）低而PRc高，而在促排卵周期中两种受体的浓度通常会大幅降低。得出的结论是，在促排卵体外受精周期中观察到的子宫内膜成熟度提前是黄体产生超生理水平的性类固醇的结果，这些性类固醇会导致子宫内膜受体动力学发生深刻改变。
