腹部肥胖与犬类心脏病有关。
Abdominal obesity is associated with heart disease in dogs.
作者信息
Thengchaisri Naris, Theerapun Wutthiwong, Kaewmokul Santi, Sastravaha Amornrate
机构信息
Department of Companion Animal Clinical Sciences, Faculty of Veterinary Medicine, Kasetsart University, 50 Pahonyothin Rd,, Lat Yao, Chatuchak, Bangkok 10900, Thailand.
出版信息
BMC Vet Res. 2014 Jun 13;10:131. doi: 10.1186/1746-6148-10-131.
BACKGROUND
The relationship between overall obesity and fat distribution in dogs and the development of heart disease is unclear. In the present study we evaluated the association between overall obesity and fat distribution and clinical heart disease by morphometric and computed tomography (CT)-based measurements. Body condition score (BCS), modified body mass index (MBMI, kg/m2), waist-to-hock-to-stifle distance ratio (WHSDR), waist-to-ilium wing distance ratio (WIWDR), and waist-to-truncal length ratio (WTLR) were compared between dogs with (n = 44) and without (n = 43) heart disease using receiver operating characteristic (ROC) analysis. Intra-abdominal fat (IAF) and subcutaneous fat (SQF) were measured in dogs with (n = 8) and without (n = 9) heart disease at the center of the fourth and fifth lumbar vertebrae by CT.
RESULTS
BCS was similar between heart disease and healthy groups (3.6 ± 0.2 vs. 3.3 ± 0.1, P = 0.126). The following morphometric measurements were greater in the heart disease group compared with healthy canines: MBMI (65.0 ± 4.5 vs. 52.5 ± 3.7 kg/m2, respectively, P = 0.035); WIWDR (4.1 ± 0.1 vs. 3.1 ± 0.1, P < 0.01); and WTLR (1.25 ± 0.04 vs. 1.05 ± 0.04, P < 0.01). However, there was no significant difference in WHSDR (3.6 ± 0.1 vs. 3.7 ± 0.2, P = 0.875). Interestingly, IAF was significantly increased in dogs with heart disease compared with healthy dogs (23.5 ± 1.5% vs. 19.4 ± 1.2%, P = 0.039) whereas SQF was similar between two groups (35.5 ± 2.7% vs. 38.6 ± 3.5%, P = 0.496). Of the five morphometric indices studied, WIWDR and WTLR provided acceptable discrimination for diagnosing heart disease in dogs, with areas under the ROC curve of 0.778 (95% confidence interval [CI]:0.683-0.874) and 0.727 (95% CI:0.619-0.835), respectively.
CONCLUSIONS
Our data indicate that abdominal obesity, rather than overall obesity, is associated with heart disease in dogs. Measurements of both WIWDR and WTLR are particular useful for detection of an abdominal obesity in dogs.
背景
犬类总体肥胖与脂肪分布和心脏病发展之间的关系尚不清楚。在本研究中，我们通过形态测量和基于计算机断层扫描（CT）的测量方法，评估了总体肥胖和脂肪分布与临床心脏病之间的关联。使用受试者工作特征（ROC）分析，比较了患有心脏病（n = 44）和未患心脏病（n = 43）的犬类之间的身体状况评分（BCS）、改良体重指数（MBMI，kg/m²）、腰至跗关节至膝关节距离比（WHSDR）、腰至髂骨翼距离比（WIWDR）和腰至躯干长度比（WTLR）。通过CT测量了患有心脏病（n = 8）和未患心脏病（n = 9）的犬类在第四和第五腰椎中心处的腹内脂肪（IAF）和皮下脂肪（SQF）。
结果
心脏病组和健康组之间的BCS相似（分别为3.6±0.2和3.3±0.1，P = 0.126）。与健康犬相比，心脏病组的以下形态测量值更大：MBMI（分别为65.0±4.5和52.5±3.7 kg/m²，P = 0.035）；WIWDR（4.1±0.1和3.1±0.1，P < 0.01）；以及WTLR（1.25±0.04和1.05±0.04，P < 0.01）。然而，WHSDR没有显著差异（3.6±0.1和3.7±0.2，P = 0.875）。有趣的是，与健康犬相比，患有心脏病的犬类IAF显著增加（23.5±1.5%对19.4±1.2%，P = 0.039），而两组之间的SQF相似（35.5±2.7%对38.6±3.5%，P = 0.496）。在所研究的五个形态学指标中，WIWDR和WTLR对诊断犬类心脏病具有可接受的辨别能力，ROC曲线下面积分别为0.778（95%置信区间[CI]：0.683 - 0.874）和0.727（95% CI：0.619 - 0.835）。
结论
我们的数据表明，腹部肥胖而非总体肥胖与犬类心脏病有关。WIWDR和WTLR的测量对于检测犬类腹部肥胖特别有用。
Zotero 插件