活检阴性、水痘带状疱疹病毒（VZV）阳性的巨细胞动脉炎、带状疱疹、VZV脑炎和缺血性视神经病变，全都集中于一人身上。
Biopsy-negative, varicella zoster virus (VZV)-positive giant cell arteritis, zoster, VZV encephalitis and ischemic optic neuropathy, all in one.
作者信息
Teodoro Tiago, Nagel Maria A, Geraldes Ruth, White Teresa, Mahalingam Ravi, Batista Paulo, Wellish Mary, Pimentel Jose, Khmeleva Nelly, Heintzman Anna, Albuquerque Luísa, Boyer Philip J, Choe Alexander, Peralta Rita, Gilden Don
机构信息
Department of Neurology, Hospital de Santa Maria, Lisbon, Portugal.
Department of Neuropathology, Hospital de Santa Maria, Lisbon, Portugal.
出版信息
J Neurol Sci. 2014 Aug 15;343(1-2):195-7. doi: 10.1016/j.jns.2014.05.035. Epub 2014 May 27.
Abstract
A 72-year-old man developed clinical features of giant cell arteritis (GCA) and ipsilateral ophthalmic-distribution zoster, followed within 2 weeks by VZV encephalitis and 2 months later by ischemic optic neuropathy. Temporal artery biopsy was histopathologically negative for GCA, but contained VZV antigen and VZV DNA in multiple non-contiguous (skip) areas. The collective clinical and laboratory findings revealed a remarkably close temporal association of zoster, multifocal VZV vasculopathy with temporal artery infection, biopsy-negative VZV-positive GCA and VZV encephalitis.
摘要
一名72岁男性出现了巨细胞动脉炎（GCA）和同侧眼支分布带状疱疹的临床特征，2周内继发水痘-带状疱疹病毒（VZV）脑炎，2个月后出现缺血性视神经病变。颞动脉活检在组织病理学上对GCA呈阴性，但在多个不连续（跳跃）区域含有VZV抗原和VZV DNA。综合临床和实验室检查结果显示，带状疱疹、多灶性VZV血管病变伴颞动脉感染、活检阴性的VZV阳性GCA和VZV脑炎在时间上存在非常密切的关联。
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本文引用的文献
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Varicella zoster virus in the temporal artery of a patient with giant cell arteritis.巨细胞动脉炎患者颞动脉中的水痘-带状疱疹病毒。
J Neurol Sci. 2013 Dec 15;335(1-2):228-30. doi: 10.1016/j.jns.2013.09.034. Epub 2013 Oct 2.
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Multifocal VZV vasculopathy with temporal artery infection mimics giant cell arteritis.多灶性 VZV 血管病伴颞动脉感染，类似于巨细胞动脉炎。
Neurology. 2013 May 28;80(22):2017-21. doi: 10.1212/WNL.0b013e318294b477. Epub 2013 May 1.
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VZV multifocal vasculopathy with ischemic optic neuropathy, acute retinal necrosis and temporal artery infection in the absence of zoster rash.VZV 多灶性血管病伴缺血性视神经病变、急性视网膜坏死和颞动脉感染，无带状疱疹皮疹。
J Neurol Sci. 2013 Feb 15;325(1-2):180-2. doi: 10.1016/j.jns.2012.12.021. Epub 2013 Jan 11.
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Varicella zoster virus ischemic optic neuropathy and subclinical temporal artery involvement.水痘带状疱疹病毒缺血性视神经病变与亚临床颞动脉受累
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