多灶性 VZV 血管病伴颞动脉感染，类似于巨细胞动脉炎。
Multifocal VZV vasculopathy with temporal artery infection mimics giant cell arteritis.
机构信息
Department of Neurology, University of Colorado School of Medicine, Aurora, CO, USA.
出版信息
Neurology. 2013 May 28;80(22):2017-21. doi: 10.1212/WNL.0b013e318294b477. Epub 2013 May 1.
Abstract
OBJECTIVE
To address the incidence of varicella-zoster virus (VZV) infection in patients with biopsy-negative giant cell arteritis (GCA), we examined archived biopsy-negative temporal arteries from subjects with clinically suspected GCA for the presence of VZV antigen.
METHODS
Formalin-fixed, paraffin-embedded temporal arteries that were pathologically negative for GCA and normal temporal arteries were analyzed immunohistochemically for VZV and herpes simplex virus-1 (HSV-1) antigen.
RESULTS
Five (21%) of 24 temporal arteries from patients who were clinically suspect but biopsy negative for GCA revealed VZV but not HSV-1 by immunohistochemical analysis. Thirteen normal temporal arteries did not contain VZV or HSV-1 antigen. All 5 subjects whose temporal arteries contained VZV antigen presented with clinical and laboratory features of GCA and early visual disturbances.
CONCLUSION
Multifocal VZV vasculopathy can present with the full spectrum of clinical features and laboratory abnormalities characteristically seen in GCA.
摘要
目的
为了研究活检阴性巨细胞动脉炎（GCA）患者水痘带状疱疹病毒（VZV）感染的发生率，我们检测了临床疑似 GCA 患者存档的活检阴性颞动脉中是否存在 VZV 抗原。
方法
对病理检查为 GCA 阴性且正常的颞动脉进行福尔马林固定、石蜡包埋，并用免疫组化方法分析 VZV 和单纯疱疹病毒-1（HSV-1）抗原。
结果
24 例临床疑似但活检阴性的 GCA 患者中，5 例（21%）颞动脉通过免疫组化分析显示 VZV，但未显示 HSV-1。13 例正常颞动脉未检出 VZV 或 HSV-1 抗原。5 例颞动脉含有 VZV 抗原的患者均表现为 GCA 的临床和实验室特征以及早期视觉障碍。
结论
多灶性 VZV 血管炎可表现为 GCA 典型的全谱临床特征和实验室异常。
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