Santiago Tânia, Rebelo Olinda, Negrão Luís, Matos Anabela
Rheumatology Unit, Centro Hospitalar e Universitário de Coimbra, Praceta Prof. Mota Pinto, 3000-075, Coimbra, Portugal,
Rheumatol Int. 2015 Jan;35(1):189-92. doi: 10.1007/s00296-014-3065-4. Epub 2014 Jun 13.
Macrophagic myofasciitis (MMF) characterized by specific muscle lesions assessing long-term persistence of aluminum hydroxide within macrophages at the site of previous immunization has been reported with increasing frequency in the past 10 years. We describe clinical and laboratory findings in patients with MMF. We did a retrospective analysis of 16 cases observed in our Neuropathology Laboratory, between January 2000 and July 2013. The mean age of the 16 patients was 48.8 ± 18.0 years; 80.0 % were female. Chronic fatigue syndrome was found in 8 of 16 patients. Half of the patients had elevated creatinine kinase levels, and 25.0 % had a myopathic electromyogram. Thirteen patients received intramuscular administration of aluminum-containing vaccine prior to the onset of symptoms. MMF may mirror a distinctive pattern of an inflammatory myopathy. The vaccines containing this adjuvant may trigger MMF in some patients.
巨噬细胞性肌炎（MMF）的特征是在先前免疫接种部位的巨噬细胞内存在评估氢氧化铝长期存留情况的特定肌肉病变，在过去10年中其报告频率不断增加。我们描述了MMF患者的临床和实验室检查结果。我们对2000年1月至2013年7月在我们神经病理学实验室观察到的16例病例进行了回顾性分析。16例患者的平均年龄为48.8±18.0岁；80.0%为女性。16例患者中有8例患有慢性疲劳综合征。一半患者的肌酸激酶水平升高，25.0%的患者有肌病性肌电图。13例患者在症状出现前接受了含铝疫苗的肌肉注射。MMF可能反映了一种独特的炎性肌病模式。含有这种佐剂的疫苗可能会在一些患者中引发MMF。
